AFLATOXIN M1

Modify Date: 2024-01-04 12:05:02

AFLATOXIN M1 Structure
AFLATOXIN M1 structure
Common Name AFLATOXIN M1
CAS Number 6795-23-9 Molecular Weight 328.273
Density 1.7±0.1 g/cm3 Boiling Point 644.3±55.0 °C at 760 mmHg
Molecular Formula C17H12O7 Melting Point 299℃
MSDS Chinese USA Flash Point 246.1±25.0 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Use of AFLATOXIN M1


Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

 Names

Name aflatoxin M1
Synonym More Synonyms

 AFLATOXIN M1 Biological Activity

Description Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].
Related Catalog
References

[1]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2017 Jan 17;7:2170.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 644.3±55.0 °C at 760 mmHg
Melting Point 299℃
Molecular Formula C17H12O7
Molecular Weight 328.273
Flash Point 246.1±25.0 °C
Exact Mass 328.058289
PSA 95.20000
LogP -0.35
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.718

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY1880000
CAS REGISTRY NUMBER :
6795-23-9
LAST UPDATED :
199510
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C17-H12-O7
MOLECULAR WEIGHT :
328.29
WISWESSER LINE NOTATION :
T F5 C6 B655 DOV GV OO QO RUT&&TTJ AQ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
320 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1728 ug/kg/76W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
DNA adduct

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
1 mg/kg
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 47,585,1971 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,51,1976 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,257,1970 TOXICOLOGY REVIEW JSIRAC Journal of Scientific and Industrial Research. (Pub. & Information Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4, 1942-45; V.22- 1963- Volume(issue)/page/year: 37,369,1978 TOXICOLOGY REVIEW ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H300-H310-H330-H350
Precautionary Statements P201-P260-P264-P280-P284-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T+,T,F,Xn
Risk Phrases 26/27/28-40-39/23/24/25-23/25-23/24/25-11-36-20/21/22
Safety Phrases S22;S45;S53;S36/S37/S39
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS GY1880000
Packaging Group I
Hazard Class 6.1(a)

 Synthetic Route

~31%

AFLATOXIN M1 Structure

AFLATOXIN M1

CAS#:6795-23-9

Literature: Buechi, George; Francisco, Manuel A.; Liesch, Jerrold M.; Schuda, Paul F. Journal of the American Chemical Society, 1981 , vol. 103, # 12 p. 3497 - 3501

~%

AFLATOXIN M1 Structure

AFLATOXIN M1

CAS#:6795-23-9

Literature: Journal of the American Chemical Society, , vol. 103, # 12 p. 3497 - 3501

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles37

More Articles
Highly sensitive and simultaneous detection of melamine and aflatoxin M1 in milk products by multiplexed planar waveguide fluorescence immunosensor (MPWFI).

Food Chem. 197 , 359-66, (2015)

Mycotoxins and industrial chemicals, such as aflatoxin M1 and melamine, now commonly exist in milk and cause potential health risks. This study presents an indirect competitive immunoassay through mul...

Carry-over of aflatoxin B1 to aflatoxin M1 in high yielding Israeli cows in mid- and late-lactation.

Toxins (Basel.) 5(1) , 173-83, (2013)

The potent hepatotoxin and carcinogen aflatoxin B1 (AFB1) is a common mycotoxin contaminant of grains used in animal feeds. Aflatoxin M1 (AFM1) is the major metabolite of AFB1 in mammals, being partia...

Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2.

Toxicon 59(6) , 644-50, (2012)

Aflatoxins are natural contaminants frequently found both in food and feed. Many of them exert immunomodulatory properties in mammals; therefore, the aim of the current study was to investigate immune...

 Synonyms

4-Hydroxyaflatoxin B1
Aflatoxin M1
Aflatoxin M1 solution
(6aR,9aR)-9a-Hydroxy-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione
Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR,9aR)-
EINECS 229-865-4
Aflatoxin M1 standard solution
BCR423RM_FLUKA
MFCD00871812