6795-23-9

6795-23-9 structure

Name: AFLATOXIN M1
Chemical Name: aflatoxin M1
CAS Number: 6795-23-9
Molecular Formula: C₁₇H₁₂O₇
Molecular Weight: 328.273
Catalog: analytical chemistry Standard Food and cosmetics standards
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-04 12:05:02
Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

Name	aflatoxin M1
Synonyms	4-Hydroxyaflatoxin B1 Aflatoxin M1 Aflatoxin M1 solution (6aR,9aR)-9a-Hydroxy-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR,9aR)- EINECS 229-865-4 Aflatoxin M1 standard solution BCR423RM_FLUKA MFCD00871812

Description	Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2017 Jan 17;7:2170.

Density	1.7±0.1 g/cm3
Boiling Point	644.3±55.0 °C at 760 mmHg
Melting Point	299℃
Molecular Formula	C₁₇H₁₂O₇
Molecular Weight	328.273
Flash Point	246.1±25.0 °C
Exact Mass	328.058289
PSA	95.20000
LogP	-0.35
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.718

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY1880000

CAS REGISTRY NUMBER :: 6795-23-9

LAST UPDATED :: 199510

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C17-H12-O7

MOLECULAR WEIGHT :: 328.29

WISWESSER LINE NOTATION :: T F5 C6 B655 DOV GV OO QO RUT&&TTJ AQ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 320 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1728 ug/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: DNA adduct

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 mg/kg

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 47,585,1971 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,51,1976 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,257,1970 TOXICOLOGY REVIEW JSIRAC Journal of Scientific and Industrial Research. (Pub. & Information Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4, 1942-45; V.22- 1963- Volume(issue)/page/year: 37,369,1978 TOXICOLOGY REVIEW ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300-H310-H330-H350
Precautionary Statements	P201-P260-P264-P280-P284-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+,T,F,Xn
Risk Phrases	26/27/28-40-39/23/24/25-23/25-23/24/25-11-36-20/21/22
Safety Phrases	S22;S45;S53;S36/S37/S39
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	GY1880000
Packaging Group	I
Hazard Class	6.1(a)

30694-05-4

30627-28-2

~31%

6795-23-9

Literature: Buechi, George; Francisco, Manuel A.; Liesch, Jerrold M.; Schuda, Paul F. Journal of the American Chemical Society, 1981 , vol. 103, # 12 p. 3497 - 3501

78596-83-5

6795-23-9

Literature: Journal of the American Chemical Society, , vol. 103, # 12 p. 3497 - 3501

Precursor 1
30694-05-4
DownStream 0

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