New synthesis of aflatoxin M1

…, MA Francisco, JM Liesch, PF Schuda

Index: Buechi, George; Francisco, Manuel A.; Liesch, Jerrold M.; Schuda, Paul F. Journal of the American Chemical Society, 1981 , vol. 103, # 12 p. 3497 - 3501

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Citation Number: 13

Abstract

Abstract: Starting with the known and readily available phloroglucinol monobenzenesulfonate (4) and 1, 4-anhydroerythritol (7), we prepared aflatoxin MI (1) in 13 steps with an overall yield of 5%. The critical features of this second synthesis of aflatoxin MI (1) include a novel approach to the tricyclic phenol 21 containing the ABC ring system, a regioselective hydrogenolysis of the benzyl protecting group at c6 in 16, and removal of ...