Furin Inhibitor II trifluoroacetate salt

Modify Date: 2024-01-10 10:49:03

Furin Inhibitor II trifluoroacetate salt structure	Common Name	Furin Inhibitor II trifluoroacetate salt
	CAS Number	673202-67-0	Molecular Weight	954.14500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₇₅N₂₅O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Furin Inhibitor II trifluoroacetate salt

Hexa-D-arginine is an inhibitor of furin.

Name	hexa-D-arginine
Synonym	More Synonyms

Description	Hexa-D-arginine is an inhibitor of furin.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Peptides
In Vitro	Hexa-D-arginine (10 μM) protects against the cytotoxic effects of anthrax toxin in RAW 264.7 cells. The concentrations of Hexa-D-arginine requires to block the cleavage of PA are similar to those required to inhibit toxicity[2].
In Vivo	Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha[1]. Rats treated with the combination of anthrax toxins and Hexa-D-arginine exhibit a 40% survival rate at 5 h compared with a control group treated solely with anthrax toxin (0% survival rate). Administration of Hexa-D-arginine (1 mg/100 μL) also results in a considerable delay in the onset of anthrax toxemia compared with results of the control group treated solely with anthrax toxin[2].
References	[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.

Molecular Formula	C₃₆H₇₅N₂₅O₆
Molecular Weight	954.14500
Exact Mass	953.63300
PSA	586.01000
LogP	2.30330
Storage condition	-20°C

FURIN INHIBITOR II

Furin Inhibitor II, Hexa-D-arginine amide

DC Chemicals Limited
China
Product Name: Furin Inhibitor II
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FURIN INHIBITOR II
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Hexa-D-arginine
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $114/1mg

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