185461-45-4

185461-45-4 structure

Name: (Sar1,Ile4.8)-Angiotensin II trifluoroacetate salt
Chemical Name: [Sar1,Ile4,8]-Angiotensin II
CAS Number: 185461-45-4
Molecular Formula: C₄₃H₇₅N₁₃O₉
Molecular Weight: 918.13700
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2016-11-01 04:53:13
Modify Date: 2024-01-22 15:44:03
(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1].

Name	[Sar1,Ile4,8]-Angiotensin II
Synonyms	(SAR1,ILE4,8)-ANGIOTENSIN II REF DUPL: Sar-Arg-Val-Ile-Ile-His-Pro-Ile-OH SAR-ARG-VAL-ILE-ILE-HIS-PRO-ILE-OH (SAR1,ILE4·8)-ANGIOTENSIN II

Description	(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Metabolic Disease
Target	Angiotensin II Type 1
In Vitro	(Sar1,Ile4,8)-Angiotensin II (30 μM；30 分钟) 增加肝细胞中胰岛素刺激的 Akt 和 GSK3α/β 磷酸化的表达[1]。
References	[1]. Sanni SJ, et al. [Sar1, Ile4, Ile8]-angiotensin II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes. Basic Clin Pharmacol Toxicol. 2018 May;122(5):460-469.