Captopril EP Impurity J

Modify Date: 2025-08-21 11:30:22

Captopril EP Impurity J Structure
Captopril EP Impurity J structure
 Common Name Captopril EP Impurity J
CAS Number 64838-55-7 Molecular Weight 259.322
Density 1.3±0.1 g/cm3 Boiling Point 464.8±40.0 °C at 760 mmHg
Molecular Formula C11H17NO4S Melting Point 76-82 °C(lit.)
MSDS Chinese USA Flash Point 234.9±27.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Captopril EP Impurity J


Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

 Names

Name N-[3-(Acetylthio)-(2S)-methylpropionyl]-L-proline hydrate
Synonym More Synonyms

 Captopril EP Impurity J Biological Activity

Description Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog
References

[1]. Li, Hp, et al. Synthesis and characterization of captopril derivatives. Res Chem Intermed 39, 621–629 (2013).

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 464.8±40.0 °C at 760 mmHg
Melting Point 76-82 °C(lit.)
Molecular Formula C11H17NO4S
Molecular Weight 259.322
Flash Point 234.9±27.3 °C
Exact Mass 259.087830
PSA 99.98000
LogP 0.40
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.549

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Synthetic Route

Proline structure

Proline

CAS#:147-85-3

~%

Captopril EP Impurity J Structure

Captopril EP Im...

CAS#:64838-55-7

Literature: Chemische Berichte, , vol. 122, p. 553 - 560
N-methacryloyl-L-proline structure

N-methacryloyl-...

CAS#:51161-88-7

Thioacetic acid structure

Thioacetic acid

CAS#:507-09-5

~%

Captopril EP Impurity J Structure

Captopril EP Im...

CAS#:64838-55-7

(R)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline structure

(R)-1-[3-(acety...

CAS#:65167-28-4

Literature: Chemische Berichte, , vol. 122, p. 553 - 560

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

EINECS 265-250-7
MFCD00792449
(S)-3-Acetylthio-2-methylpropionyl-L-proline
L-Proline, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-
1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-proline
(2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline
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