23500-15-4

23500-15-4 structure

Name: Captopril EP Impurity E
Chemical Name: (2S)-1-(2-methylpropanoyl)pyrrolidine-2-carboxylic acid
CAS Number: 23500-15-4
Molecular Formula: C₉H₁₅NO₃
Molecular Weight: 185.22000
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-06-17 20:08:25
Modify Date: 2024-01-10 18:45:20
Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

Name	(2S)-1-(2-methylpropanoyl)pyrrolidine-2-carboxylic acid
Synonyms	L-Proline,1-(2-methyl-1-oxopropyl) (2S)-1-(2-Methylpropanoyl)pyrrolidine-2-carboxylic acid,1-Isobutyryl-L-proline UNII-27JC6R80S1 L-1-Isobutyrylproline Captopril Impurity 6

Description	Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL. [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.