Captopril EP Impurity J

Names

[ Name ]:
Captopril EP Impurity J

[Synonym ]:
EINECS 265-250-7
MFCD00792449
(S)-3-Acetylthio-2-methylpropionyl-L-proline
L-Proline, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-
1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-proline
(2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline

Biological Activity

[Description]:

Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Li, Hp, et al. Synthesis and characterization of captopril derivatives. Res Chem Intermed 39, 621–629 (2013).

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
464.8±40.0 °C at 760 mmHg

[ Melting Point ]:
76-82 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₇NO₄S

[ Molecular Weight ]:
259.322

[ Flash Point ]:
234.9±27.3 °C

[ Exact Mass ]:
259.087830

[ PSA ]:
99.98000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.549

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%