Proline

Names

[ CAS No. ]:
147-85-3

[ Name ]:
Proline

[Synonym ]:
(-)-Proline
BYL719
Proline
Proline, L-
(-)-(S)-proline
(2S)-proline
pyrrolidine-2-carbonic acid
(2S)-2-Pyrrolidinecarboxylic acid
(S)-2-Carboxypyrrolidine
(-)-2-Pyrrolidinecarboxylic acid
2-Pyrrolidinecarboxylic acid
(−)-proline
(S)-proline
EINECS 210-189-3
2-Pyrrolidinecarboxylicacid
L(-)-Proline
(2S)-pyrrolidine-2-carboxylic acid
MFCD00064318
(−)-2-pyrrolidinecarboxylic acid
(−)-(S)-proline
(S)-(-)-Pyrrolidine-2-carboxylic acid
L-a-Pyrrolidinecarboxylic Acid
(S)-(-)-Proline
(l)-proline
l-Pro
QCR-1
(S)-Pyrrolidine-2-carboxylic acid,L-Proline
EINECS 205-702-2
L-(-)-proline
L-pyrrolidine-2-carboxylic acid
2-Pyrrolidinecarboxylic acid, (S)-
(S)-Pyrrolidine-2-carboxylic acid

Biological Activity

[Description]:

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

[Related Catalog]:

Research Areas >> Others

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
252.2±33.0 °C at 760 mmHg

[ Melting Point ]:
228 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₉NO₂

[ Molecular Weight ]:
115.131

[ Flash Point ]:
106.3±25.4 °C

[ Exact Mass ]:
115.063332

[ PSA ]:
49.33000

[ LogP ]:
-0.57

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.487

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3584000

CHEMICAL NAME :: Proline, L-

CAS REGISTRY NUMBER :: 147-85-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H9-N-O2

MOLECULAR WEIGHT :: 115.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81957 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81957 No. of Facilities: 762 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 18391 (estimated) No. of Female Employees: 13943 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TW3584000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.

Microb. Cell Fact. 14 , 108, (2015)

Understanding the metabolism of the microbial host is essential for the development and optimization of whole-cell based biocatalytic processes, as it dictates production efficiency. This is especiall...

Injectable microcarriers as human mesenchymal stem cell support and their application for cartilage and degenerated intervertebral disc repair.

Eur. Cell. Mater. 29 , 70-80; discujssion 80-1, (2015)

Degeneration of the intervertebral disc (IVD) is a progressive and chronic process, and the high incidence of discogenic disorders calls for new therapeutic approaches, such as cell-based therapies us...