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Captopril EP Impurity E

Names

[ CAS No. ]:
23500-15-4

[ Name ]:
Captopril EP Impurity E

[Synonym ]:
L-Proline,1-(2-methyl-1-oxopropyl)
(2S)-1-(2-Methylpropanoyl)pyrrolidine-2-carboxylic acid,1-Isobutyryl-L-proline
UNII-27JC6R80S1
L-1-Isobutyrylproline
Captopril Impurity 6

Biological Activity

[Description]:

Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

[ Melting Point ]:
122.6-123.7℃

[ Molecular Formula ]:
C9H15NO3

[ Molecular Weight ]:
185.22000

[ Exact Mass ]:
185.10500

[ PSA ]:
57.61000

[ LogP ]:
0.65590

Related Compounds