N-Methyl-D-aspartic acid

Modify Date: 2025-08-21 16:43:30

N-Methyl-D-aspartic acid Structure
N-Methyl-D-aspartic acid structure
 Common Name N-Methyl-D-aspartic acid
CAS Number 6384-92-5 Molecular Weight 147.129
Density 1.3±0.1 g/cm3 Boiling Point 258.2±30.0 °C at 760 mmHg
Molecular Formula C5H9NO4 Melting Point 187-192 °C
MSDS Chinese USA Flash Point 110.0±24.6 °C

 Use of N-Methyl-D-aspartic acid


NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

 Names

Name N-Methyl-D-aspartic acid
Synonym More Synonyms

 N-Methyl-D-aspartic acid Biological Activity

Description NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
Related Catalog
In Vitro NMDA exerts a significant augmentation of the adrenal binding independently of the incubation temperature in a concentration-dependent manner[2].
In Vivo NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN[1].
Kinase Assay Adrenal membranous homogenate suspensions are incubated with 10 nM [3H]Glu in 500/zl 50 mM Tris-acetate buffer (pH 7.4) at 2°C or 30°C in the presence and absence of various compounds. Incubation is terminated by the addition of 3 mL ice-cold buffer and subsequent filtration through a Whatman GF/B glass filter under a constant vacuum of 15 mm Hg. After washing the filter 4 times with 3 mL icecold buffer, the radioactivity trapped on the filter is measured by a liquid scintillation spectrometer using 5 mL modified Triton-toluene scintillant at a counting efficiency of 40-42%. The radioactivity found in the presence of 1 mM non-radioactive Glu is subtracted from each experimental value to obtain the specific binding of [3H]GIu in accordance with the y-aminobutyric acid (GABA) receptor binding assay system. The kinetic parameters of [3H]GIu binding, Kd and Bma x, are calculated by Scatchard analysis of the specific binding using a personal computer with a programme for non-linear regression analysis developed in our own laboratory.
Animal Admin Thirty male rats are paired with different receptive females for a total of three times (once every 3 days) a week prior to the experiment, only the males that ejaculated at least three times during this period are included. After selecting the male rats with normal ejaculatory ability. Saline (100 nL), NMDA (0.20 nmol in 100 nL saline), and AP-5 (10.0 nmol in 100 nL saline) are adminitration into the bilateral PVN of each male rat in random order. After 5 min, the behavioral testing is performed and recorded as described above. Copulatory behaviors occur once a week and the entire experiment lasted 4 weeks.
References

[1]. Xia JD, et al. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus. Andrology. 2016 Nov 16.

[2]. Yoneda Y, et al. Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal. Brain Res. 1987 Mar 17;406(1-2):24-31.

[3]. Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation. Neuroreport. 2017 May 24;28(8):444-450.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 258.2±30.0 °C at 760 mmHg
Melting Point 187-192 °C
Molecular Formula C5H9NO4
Molecular Weight 147.129
Flash Point 110.0±24.6 °C
Exact Mass 147.053162
PSA 86.63000
LogP -0.44
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.494
InChIKey HOKKHZGPKSLGJE-GSVOUGTGSA-N
SMILES CNC(CC(=O)O)C(=O)O
Water Solubility slightly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI9457000
CHEMICAL NAME :
D-Aspartic acid, N-methyl-
CAS REGISTRY NUMBER :
6384-92-5
BEILSTEIN REFERENCE NO. :
1724431
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H9-N-O4
MOLECULAR WEIGHT :
147.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
137 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 269,573,1994

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CI9457000
HS Code 2942000000

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles331

More Articles
Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....

Glutamatergic receptor dysfunction in spinal cord contributes to the exaggerated exercise pressor reflex in heart failure.

Am. J. Physiol. Heart Circ. Physiol. 308(5) , H447-55, (2015)

Excitatory amino acids (e.g., glutamate) released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor refl...

Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.

J. Pharmacol. Exp. Ther. 353(1) , 91-101, (2015)

N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 63...

 Synonyms

N-Methylaspartic acid
DL-Aspartic acid, N-methyl-
N-Methyl-DL-Aspartic acid
EINECS 227-012-0
DL-2-METHYLAMINOSUCCINIC ACID
D-Aspartic acid, N-methyl-
Aspartic acid, N-methyl-
N-Me-D-Asp-OH
(2R)-2-(methylamino)butanedioic acid
UNII:EU52DFC4WJ
NMDA
N-Methyl--aspartic acid
MFCD06795789
N-Methyl aspartic acid
N-Methyl-D-aspartic acid
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