Salsolidine hydrochloride

Modify Date: 2024-01-09 19:11:06

Salsolidine hydrochloride structure	Common Name	Salsolidine hydrochloride
	CAS Number	63283-42-1	Molecular Weight	243.73
	Density	N/A	Boiling Point	313.4ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₈ClNO₂	Melting Point	189-192ºC
	MSDS	N/A	Flash Point	127.1ºC

Use of Salsolidine hydrochloride

Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

Name	6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline,hydrochloride
Synonym	More Synonyms

Description	Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO A[1]
In Vitro	Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki=6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting acetylcholinestearse and butyrylcholinesterase[3].
References	[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,263,1942

6,7-Dimethoxy-1...

CAS#:4721-98-6

~93%

Salsolidine hyd...

CAS#:63283-42-1

Literature: Glusa; Gruner; Hagen; Lohmann; Foken Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410

Acetamide, N-(3...

CAS#:6275-29-2

Salsolidine hyd...

CAS#:63283-42-1

3,4-Dimethoxyph...

CAS#:120-20-7

Salsolidine hyd...

CAS#:63283-42-1

Precursor 3
CAS#:4721-98-6 6,7-Dimethoxy-1... CAS#:6275-29-2 Acetamide, N-(3... CAS#:120-20-7 3,4-Dimethoxyph...
DownStream 2
CAS#:59709-57-8 6,7-Isoquinolin... CAS#:525-72-4 (R)-1-METHYL-1,...