63283-42-1

63283-42-1 structure

Name: Salsolidine hydrochloride
Chemical Name: 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline,hydrochloride
CAS Number: 63283-42-1
Molecular Formula: C₁₂H₁₈ClNO₂
Molecular Weight: 243.73
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2019-01-01 21:12:49
Modify Date: 2025-08-25 16:18:02
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

Name	6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline,hydrochloride
Synonyms	Salsolidine hydrochloride Prestwick_860 Isoquinoline,6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro,hydrochloride Salsolidin*HCl

Description	Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO A[1]
In Vitro	Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki=6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting acetylcholinestearse and butyrylcholinesterase[3].
References	[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, hydrochloride

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,263,1942

4721-98-6

~93%

63283-42-1

Literature: Glusa; Gruner; Hagen; Lohmann; Foken Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410

6275-29-2

63283-42-1

Literature: Pharmazie, , vol. 45, # 6 p. 408 - 410

120-20-7

63283-42-1

Literature: Pharmazie, , vol. 45, # 6 p. 408 - 410