SKF-75670

Modify Date: 2024-01-02 19:47:23

SKF-75670 structure	Common Name	SKF-75670
	CAS Number	62717-63-9	Molecular Weight	350.25
	Density	N/A	Boiling Point	450.1ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₀BrNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	241ºC

Use of SKF-75670

SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist[1][2][3].

Name	3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol,hydrobromide
Synonym	More Synonyms

Description	SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor
In Vivo	SKF-75670 hydrochloride (2.5-10 mg/kg，腹腔注射) 降低 MPTP 处理的狨猴的运动活性[2]。 SKF-75670 hydrochloride (0.3 和 1.0 mg/kg，肌肉注射) 拮抗可卡因对猴子的速率改变和辨别刺激作用[3]。 Animal Model: MPTP-treated marmosets[2] Dosage: 2.5-10 mg/kg Administration: i.p. Result: Reduced locomotor activity (marmosets were largely immobile and appeared sedated and had a flexed posture).
References	[1]. Rosenzweig-Lipson S, et al. Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75. [2]. Gnanalingham KK, et al. Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset. Psychopharmacology (Berl). 1995 Feb;117(3):275-86. [3]. Spealman RD, et al. Differential modulation of behavioral effects of cocaine by low- and high-efficacy D1 agonists. Psychopharmacology (Berl). 1997 Oct;133(3):283-92.

Boiling Point	450.1ºC at 760 mmHg
Molecular Formula	C₁₇H₂₀BrNO₂
Molecular Weight	350.25
Flash Point	241ºC
Exact Mass	349.06800
PSA	43.70000
LogP	3.61360

(+)-(R)-1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benz[d]azepine structure

(+)-(R)-1-pheny...

CAS#:56030-50-3

~83%

SKF-75670 Structure

SKF-75670

CAS#:62717-63-9

Literature: Kaiser; Dandridge; Garvey; Hahn; Sarau; Setler; Bass; Clardy Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 697 - 703

7,8-Dimethoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi ne structure

7,8-Dimethoxy-3...

CAS#:20012-08-2

~%

SKF-75670 Structure

SKF-75670

CAS#:62717-63-9

Literature: Kaiser; Dandridge; Garvey; Hahn; Sarau; Setler; Bass; Clardy Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 697 - 703

(R)-2,3,4,5-tetrahydro-7,8-dihydroxy-3-methyl-1-phenyl-1H-3-benzazepine hydrobromide

7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

DC Chemicals Limited
China
Product Name: SKF-75670
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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