SKF-75670

Names

[ Name ]:
SKF-75670

[Synonym ]:
(R)-2,3,4,5-tetrahydro-7,8-dihydroxy-3-methyl-1-phenyl-1H-3-benzazepine hydrobromide
7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Biological Activity

[Description]:

SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D1 Receptor

[In Vivo]

SKF-75670 hydrochloride (2.5-10 mg/kg，腹腔注射) 降低 MPTP 处理的狨猴的运动活性[2]。 SKF-75670 hydrochloride (0.3 和 1.0 mg/kg，肌肉注射) 拮抗可卡因对猴子的速率改变和辨别刺激作用[3]。 Animal Model: MPTP-treated marmosets[2] Dosage: 2.5-10 mg/kg Administration: i.p. Result: Reduced locomotor activity (marmosets were largely immobile and appeared sedated and had a flexed posture).

[References]

[1]. Rosenzweig-Lipson S, et al. Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75.

[2]. Gnanalingham KK, et al. Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset. Psychopharmacology (Berl). 1995 Feb;117(3):275-86.

[3]. Spealman RD, et al. Differential modulation of behavioral effects of cocaine by low- and high-efficacy D1 agonists. Psychopharmacology (Berl). 1997 Oct;133(3):283-92.

Chemical & Physical Properties

[ Boiling Point ]:
450.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀BrNO₂

[ Molecular Weight ]:
350.25

[ Flash Point ]:
241ºC

[ Exact Mass ]:
349.06800

[ PSA ]:
43.70000

[ LogP ]:
3.61360

SKF-75670

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds