SKF 77434 hydrobromide

Names

[ Name ]:
SKF 77434 hydrobromide

[Synonym ]:
(+/-)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
Atrial natriuretic factor (1-28) (human,porcine)

Biological Activity

[Description]:

SKF 77434 hydrobromide is a selective dopamine D1 receptor partial agonist. SKF 77434 hydrobromide has the potential to study cocaine addiction[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Cohen C, et al. Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology (Berl). 1999 Feb;142(1):102-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂BrNO₂

[ Molecular Weight ]:
376.29

[ Exact Mass ]:
375.08300

[ PSA ]:
43.70000

[ LogP ]:
4.16980

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.

J. Neurosci. 22(22) , 9841-9, (2002)

The dynamics of dopamine receptor signaling efficacy were characterized in developing mice by measuring striatal c-Fos expression after dopaminergic agonist treatment at postnatal day 4 (P4) to P18. C...

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

Proc. Natl. Acad. Sci. U. S. A. 96(9) , 5280-5, (1999)

To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hipp...

Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity.

J. Pharmacol. Exp. Ther. 262(2) , 855-65, (1992)

Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound beha...