Myristicin

Modify Date: 2024-01-03 04:01:30

Myristicin structure	Common Name	Myristicin
	CAS Number	607-91-0	Molecular Weight	192.211
	Density	1.1±0.1 g/cm3	Boiling Point	276.5±0.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂O₃	Melting Point	<-20ºC
	MSDS	Chinese USA	Flash Point	89.8±16.0 °C
	Symbol	GHS08	Signal Word	Warning

Use of Myristicin

Myristicine act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others[1].

Name	4-methoxy-6-prop-2-enyl-1,3-benzodioxole
Synonym	More Synonyms

Description	Myristicine act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4. [2]. Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31(1):119-123. Epub 2012 Aug 15.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

References

[1]. Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4.

[2]. Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31(1):119-123. Epub 2012 Aug 15.

Density	1.1±0.1 g/cm3
Boiling Point	276.5±0.0 °C at 760 mmHg
Melting Point	<-20ºC
Molecular Formula	C₁₁H₁₂O₃
Molecular Weight	192.211
Flash Point	89.8±16.0 °C
Exact Mass	192.078644
PSA	27.69000
LogP	3.26
Appearance of Characters	oil \| clear, light yellow
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.540

Myristicin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY2625000

CHEMICAL NAME :: Benzene, 5-allyl-1-methoxy-2,3-(methylenedioxy)-

CAS REGISTRY NUMBER :: 607-91-0

BEILSTEIN REFERENCE NO. :: 0166218

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H12-O3

MOLECULAR WEIGHT :: 192.23

WISWESSER LINE NOTATION :: T56 BO DO CHJ FO1 H2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5700 ug/kg

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - euphoria Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Liver - fatty liver degeneration

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361f-H412
Precautionary Statements	P201-P273-P308 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn
Risk Phrases	R52/53
Safety Phrases	S61
RIDADR	UN 3082 9/PG 3
WGK Germany	1
RTECS	CY2625000
Hazard Class	9.0
HS Code	2932999099

Precursor 7
CAS#:4055-72-5 Pyrocatechol CAS#:74-95-3 Dibromomethane CAS#:71186-63-5 2-allyloxy-3-me... CAS#:75-11-6 Diiodomethane
CAS#:97-53-0 Eugenol CAS#:22934-51-6 5-Allyl-2-hydro... CAS#:67-64-1 Acetone
DownStream 10
CAS#:111394-44-6 (Z)-2-Methoxy-5... CAS#:18312-21-5 TRANS-ISOMYRISTICIN CAS#:5780-07-4 myristicin aldehyde CAS#:22934-58-3 Myristicin acid...
CAS#:22934-59-4 7-METHOXY-1,3-B... CAS#:23693-38-1 2-(7-methoxy-1,... CAS#:54306-09-1 3-(7-methoxy-1,... CAS#:526-34-1 3-METHOXY-4,5-M...
CAS#:4408-61-1 (7-methoxy-benz... CAS#:52811-28-6 Dihydromyristicin

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.

Chem. Biol. Interact. 218 , 1-9, (2014)

Myristicin, an allylbenzene, is a major active component of various spices, such as nutmeg and cinnamon, plants from the Umbelliferae family or in some essential oils, such as oils of clove or marjora...

Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects.

J. Toxicol. Environ. Health. B. Crit. Rev. 15(6) , 365-95, (2012)

The methylenedioxyphenyl (MDP) substituent is a structural feature present in many plant chemicals that deter foraging by predatory insects and herbivores. With increasing use of herbal extracts in al...

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.

Nat. Prod. Commun. 8(9) , 1305-8, (2013)

We have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analys...

myristicine

4-methoxy-6-prop-2-en-1-yl-1,3-benzodioxole

6-Allyl-4-methoxy-1,3-benzodioxole

1,3-Benzodioxole, 4-methoxy-6-(2-propen-1-yl)-

MFCD00133549

Myristicin

4-Méthoxy-6-(2-propèn-1-yl)-1,3-benzodioxole

3-methoxy-4,5-methylenedioxyallylbenzene

1-allyl-4,5-methylenedioxy-3-methoxybenzene

EINECS 210-146-9

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Myristicin
Price: ￥1378.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Myristicin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Myristicin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: myristicin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Myristicin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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