Oxindole

Modify Date: 2024-01-02 16:07:04

Oxindole structure	Common Name	Oxindole
	CAS Number	59-48-3	Molecular Weight	133.147
	Density	1.3±0.1 g/cm3	Boiling Point	312.8±45.0 °C at 760 mmHg
	Molecular Formula	C₈H₇NO	Melting Point	123-128 °C(lit.)
	MSDS	Chinese USA	Flash Point	190.0±18.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Oxindole

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

Name	indolin-2-one
Synonym	More Synonyms

Description	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Metabolic Disease Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold[1]. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities[2].
References	[1]. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat. 2016;26(2):149-73. [2]. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894.

Density	1.3±0.1 g/cm3
Boiling Point	312.8±45.0 °C at 760 mmHg
Melting Point	123-128 °C(lit.)
Molecular Formula	C₈H₇NO
Molecular Weight	133.147
Flash Point	190.0±18.0 °C
Exact Mass	133.052765
PSA	29.10000
LogP	0.61
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.640
Storage condition	Refrigerator
Water Solubility	insoluble

Oxindole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2080500

CHEMICAL NAME :: 2-Indolinone

CAS REGISTRY NUMBER :: 59-48-3

BEILSTEIN REFERENCE NO. :: 0114692

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H7-N-O

MOLECULAR WEIGHT :: 133.16

WISWESSER LINE NOTATION :: T56 BMV DHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,121,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,121,1964

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	2811
WGK Germany	3
RTECS	NM2080500
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29337900

Precursor 10
CAS#:91-56-5 isatin CAS#:120-72-9 Indole CAS#:30095-98-8 methyl 2-(2-nit... CAS#:3740-52-1 (2-Nitrophenyl)...
CAS#:5339-85-5 2-(2-Aminopheny... CAS#:628-21-7 1,4-Diiodobutane CAS#:109-72-8 n-Butyllithium CAS#:110-18-9 TMEDA
CAS#:2365-44-8 1H-Indole-2,3-d... CAS#:65816-14-0 1,3-dihydro-1-M...
DownStream 9
CAS#:496-30-0 3H-Indole-2-thiol CAS#:496-15-1 Indoline CAS#:3342-78-7 2-Aminophenylac... CAS#:607-28-3 1H-indole-2,3-d...
CAS#:3335-98-6 1-Phenyloxindole CAS#:3416-18-0 5-HYDROXYOXINDOLE CAS#:14370-71-9 Acetic acid,2-(... CAS#:141210-63-1 3-(dimethylamin...
CAS#:479-41-4 Indirubin

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Cytotoxic and antimicrobial evaluations of novel apoptotic and anti-angiogenic spiro cyclic 2-oxindole derivatives of 2-amino-tetrahydroquinolin-5-one.

Arch. Pharm. (Weinheim) 348(2) , 113-24, (2015)

A novel series of cyclic 2-oxindole derivatives incorporating 2-amino-tetrahydroquinolin-5-one were prepared. The structures of the prepared compounds were elucidated using different spectral tools. T...

Synthesis and biological evaluation of new pyridone-annelated isoindigos as anti-proliferative agents.

Molecules 19(9) , 13076-92, (2014)

A selected set of substituted pyridone-annelated isoindigos 3a-f has been synthesized via interaction of 5- and 6-substituted oxindoles 2a-f with 6-ethyl-1,2,9-trioxopyrrolo[3,2-f]quinoline-8-carboxyl...

Synthesis and receptor binding assay of indolin-2-one derivatives as dopamine D4 receptor ligands.

Pharmazie 70 , 511-4, (2015)

Five indolin-2-one derivatives bearing piperazinylbutyl side chains attached to the amide nitrogen were synthesized from 2-indolinone. 1-(4-Bromobutyl)-indolin-2-one was reacted with 1-piperazinecarbo...

Oxindole

3H-Indol-2-ol

2-INDOLINONE

2-indolinon

2-Oxindoline

2-oxo-indoline

EINECS 200-429-5

OXINDOL

indolinone

1,3-Dihydro-2H-indol-2-one

2-Indolone

2H-Indol-2-one, 1,3-dihydro-

Indolin-2-one

2-Oxiindole

MFCD00005711

2-Oxindole

1,3-dihydro-indol-2-one

BioBioPha
China
Product Name: Oxindole
Price: ￥Inquiry/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Oxindole
Price: ￥188.0/25g ￥568.0/100g
Purity: 98.0%
Stocking Period: 2 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Oxindole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Oxindole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: ￥550/10 mM * 1 mL in DMSO

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