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Shanghai Jizhi Biochemical Technology Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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59-48-3

59-48-3 structure

59-48-3 structure

Name: Oxindole
Chemical Name: indolin-2-one
CAS Number: 59-48-3
Molecular Formula: C₈H₇NO
Molecular Weight: 133.147
Catalog: Natural product Alkaloid
Create Date: 2018-04-18 08:00:00
Modify Date: 2024-01-02 16:07:04
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

Name	indolin-2-one
Synonyms	Oxindole 3H-Indol-2-ol 2-INDOLINONE 2-indolinon 2-Oxindoline 2-oxo-indoline EINECS 200-429-5 OXINDOL indolinone 1,3-Dihydro-2H-indol-2-one 2-Indolone 2H-Indol-2-one, 1,3-dihydro- Indolin-2-one 2-Oxiindole MFCD00005711 2-Oxindole 1,3-dihydro-indol-2-one

Description	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Metabolic Disease Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold[1]. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities[2].
References	[1]. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat. 2016;26(2):149-73. [2]. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894.

Density	1.3±0.1 g/cm3
Boiling Point	312.8±45.0 °C at 760 mmHg
Melting Point	123-128 °C(lit.)
Molecular Formula	C₈H₇NO
Molecular Weight	133.147
Flash Point	190.0±18.0 °C
Exact Mass	133.052765
PSA	29.10000
LogP	0.61
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.640
Storage condition	Refrigerator
Water Solubility	insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2080500

CHEMICAL NAME :: 2-Indolinone

CAS REGISTRY NUMBER :: 59-48-3

BEILSTEIN REFERENCE NO. :: 0114692

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H7-N-O

MOLECULAR WEIGHT :: 133.16

WISWESSER LINE NOTATION :: T56 BMV DHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,121,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,121,1964

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	2811
WGK Germany	3
RTECS	NM2080500
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29337900

Precursor 10
91-56-5 120-72-9 30095-98-8 3740-52-1
5339-85-5 628-21-7 109-72-8 110-18-9
2365-44-8 65816-14-0
DownStream 9
496-30-0 496-15-1 3342-78-7 607-28-3
3335-98-6 3416-18-0 14370-71-9 141210-63-1
479-41-4

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%