Kainic acid hydrate

Modify Date: 2024-01-02 17:01:26

Kainic acid hydrate structure	Common Name	Kainic acid hydrate
	CAS Number	58002-62-3	Molecular Weight	213.230
	Density	1.2±0.1 g/cm3	Boiling Point	439.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₅NO₄	Melting Point	250-252°C
	MSDS	USA	Flash Point	219.8±28.7 °C

Use of Kainic acid hydrate

Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].

Name	(−)-(α)-Kainic Acid
Synonym	More Synonyms

Description	Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vivo	Kainic acid hydrate (5 mg/kg；腹腔注射；每小时一次至少 3 小时，直至癫痫持续状态) 诱导大鼠癫痫发作[1]。 Animal Model: 8 weeks, 200-250 g male adult Wistar rats[1] Dosage: 5 mg/kg Administration: I.p.; hourly at least 3 h until status epilepticus Result: Induced seizures in rats.
References	[1]. Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909. [2]. Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16.

Density	1.2±0.1 g/cm3
Boiling Point	439.9±45.0 °C at 760 mmHg
Melting Point	250-252°C
Molecular Formula	C₁₀H₁₅NO₄
Molecular Weight	213.230
Flash Point	219.8±28.7 °C
Exact Mass	213.100113
LogP	0.50
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.509

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22;S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

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kainic acid

MFCD00150833

(3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline

(−)-Kainic Acid

L-Proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-