Kainic acid hydrate

Names

[ Name ]:
Kainic acid hydrate

[Synonym ]:
kainic acid
MFCD00150833
(3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline
(−)-Kainic Acid
L-Proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-

Biological Activity

[Description]:

Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vivo]

Kainic acid hydrate (5 mg/kg；腹腔注射；每小时一次至少 3 小时，直至癫痫持续状态) 诱导大鼠癫痫发作[1]。 Animal Model: 8 weeks, 200-250 g male adult Wistar rats[1] Dosage: 5 mg/kg Administration: I.p.; hourly at least 3 h until status epilepticus Result: Induced seizures in rats.

[References]

[1]. Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909.

[2]. Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
439.9±45.0 °C at 760 mmHg

[ Melting Point ]:
250-252°C

[ Molecular Formula ]:
C₁₀H₁₅NO₄

[ Molecular Weight ]:
213.230

[ Flash Point ]:
219.8±28.7 °C

[ Exact Mass ]:
213.100113

[ LogP ]:
0.50

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.509

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.

Sci. Rep. 5 , 12448, (2015)

Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epile...

Nodule excitability in an animal model of periventricular nodular heterotopia: c-fos activation in organotypic hippocampal slices.

Epilepsia 56(4) , 626-35, (2015)

Aberrations in brain development may lead to dysplastic structures such as periventricular nodules. Although these abnormal collections of neurons are often associated with difficult-to-control seizur...

Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.

Stem Cells Dev. 22(10) , 1506-21, (2013)

Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+...