Zoledronic acid hydrate

Modify Date: 2024-01-02 13:41:13

Zoledronic acid hydrate Structure
Zoledronic acid hydrate structure
Common Name Zoledronic acid hydrate
CAS Number 165800-06-6 Molecular Weight 290.105
Density N/A Boiling Point 764ºC at 760 mmHg
Molecular Formula C5H12N2O8P2 Melting Point 245 °C(dec.)
MSDS Chinese USA Flash Point 415.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Zoledronic acid hydrate


Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

 Names

Name Zoledronic acid hydrate
Synonym More Synonyms

 Zoledronic acid hydrate Biological Activity

Description Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Related Catalog
In Vitro Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
References

[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6.

[2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

 Chemical & Physical Properties

Boiling Point 764ºC at 760 mmHg
Melting Point 245 °C(dec.)
Molecular Formula C5H12N2O8P2
Molecular Weight 290.105
Flash Point 415.8ºC
Exact Mass 290.006897
PSA 181.96000
Vapour Pressure 1.53E-24mmHg at 25°C
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2933290090

 Synthetic Route

~88%

Zoledronic acid hydrate Structure

Zoledronic acid...

CAS#:165800-06-6

Literature: GADOR S.A. Patent: WO2007/16982 A1, 2007 ; Location in patent: Page/Page column 7-8 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

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 Synonyms

(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate
Zoledronic acid monohydrate
Reclast
Zometa
[1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1)
Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate
MFCD08448695
Aclasta
1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1)
Zoledronic acid hydrate
Zoledronic acid
Zoledronic acid (monohydrate)
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