Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Zoledronic acid hydrate
Price: ￥2088.0/5g ￥588.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Zoledronic acid hydrate
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Zoledronic acid injection
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Zoledronic acid hydrate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

165800-06-6

165800-06-6 structure

165800-06-6 structure

Name: Zoledronic acid hydrate
Chemical Name: Zoledronic acid hydrate
CAS Number: 165800-06-6
Molecular Formula: C₅H₁₂N₂O₈P₂
Molecular Weight: 290.105
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-04-15 08:00:00
Modify Date: 2024-01-02 13:41:13
Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

Name	Zoledronic acid hydrate
Synonyms	(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate Zoledronic acid monohydrate Reclast Zometa [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1) Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1) (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate MFCD08448695 Aclasta 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1) Zoledronic acid hydrate Zoledronic acid Zoledronic acid (monohydrate)

Description	Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
In Vitro	Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
References	[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

Boiling Point	764ºC at 760 mmHg
Melting Point	245 °C(dec.)
Molecular Formula	C₅H₁₂N₂O₈P₂
Molecular Weight	290.105
Flash Point	415.8ºC
Exact Mass	290.006897
PSA	181.96000
Vapour Pressure	1.53E-24mmHg at 25°C
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2933290090

118072-93-8 structure

118072-93-8

~88%

165800-06-6 structure

165800-06-6

Literature: GADOR S.A. Patent: WO2007/16982 A1, 2007 ; Location in patent: Page/Page column 7-8 ;

Precursor 1
118072-93-8
DownStream 0

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%