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165800-06-6

165800-06-6 structure
165800-06-6 structure
  • Name: Zoledronic acid hydrate
  • Chemical Name: Zoledronic acid hydrate
  • CAS Number: 165800-06-6
  • Molecular Formula: C5H12N2O8P2
  • Molecular Weight: 290.105
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-04-15 08:00:00
  • Modify Date: 2025-08-24 20:50:32
  • Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Name Zoledronic acid hydrate
Synonyms (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate
Zoledronic acid monohydrate
Reclast
Zometa
[1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1)
Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate
MFCD08448695
Aclasta
1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1)
Zoledronic acid hydrate
Zoledronic acid
Zoledronic acid (monohydrate)
Description Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Related Catalog
In Vitro Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
References

[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6.

[2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

Boiling Point 764ºC at 760 mmHg
Melting Point 245 °C(dec.)
Molecular Formula C5H12N2O8P2
Molecular Weight 290.105
Flash Point 415.8ºC
Exact Mass 290.006897
PSA 181.96000
Vapour Pressure 1.53E-24mmHg at 25°C
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2933290090
118072-93-8 structure

118072-93-8

~88%

165800-06-6 structure

165800-06-6

Literature: GADOR S.A. Patent: WO2007/16982 A1, 2007 ; Location in patent: Page/Page column 7-8 ;
Precursor  1

DownStream  0

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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