Zoledronic acid
Modify Date: 2025-08-20 12:01:48
Zoledronic acid structure
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Common Name | Zoledronic acid | ||
|---|---|---|---|---|
| CAS Number | 118072-93-8 | Molecular Weight | 272.090 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 764.0±70.0 °C at 760 mmHg | |
| Molecular Formula | C5H10N2O7P2 | Melting Point | 193-2040ºC | |
| MSDS | N/A | Flash Point | 415.8±35.7 °C | |
Use of Zoledronic acidZoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. |
| Name | zoledronic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. |
|---|---|
| Related Catalog | |
| In Vitro | Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2]. |
| References |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 764.0±70.0 °C at 760 mmHg |
| Melting Point | 193-2040ºC |
| Molecular Formula | C5H10N2O7P2 |
| Molecular Weight | 272.090 |
| Flash Point | 415.8±35.7 °C |
| Exact Mass | 271.996338 |
| PSA | 172.73000 |
| LogP | -2.28 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.719 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R21/22 |
| Safety Phrases | 24/25-36/37/39 |
| HS Code | 2933290090 |
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~99%
Zoledronic acid CAS#:118072-93-8 |
| Literature: Synthon B.V. Patent: EP2192126 A1, 2010 ; Location in patent: Page/Page column 9 ; |
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Zoledronic acid CAS#:118072-93-8 |
| Literature: Letters in Drug Design and Discovery, , vol. 9, # 4 p. 345 - 351 |
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Zoledronic acid CAS#:118072-93-8 |
| Literature: Acta Crystallographica Section C: Crystal Structure Communications, , vol. 69, # 3 p. 263 - 266 |
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~%
Zoledronic acid CAS#:118072-93-8 |
| Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 188, # 1-3 p. 39 - 41 |
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Zoledronic acid CAS#:118072-93-8 |
| Literature: Russian Journal of General Chemistry, , vol. 82, # 6 p. 1178 - 1179,2 Zhurnal Obshchei Khimii, , vol. 82, # 6 p. 1044 - 1045,2 |
CAS#:165800-06-6| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| zoledronate |
| Zoledronic acid monohydrate |
| P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate |
| acide [1-hydroxy-2-(1H-imidazol-1-yl)éthane-1,1-diyl]bis(phosphonique) |
| hydrogen [1-hydroxy-2-(1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate |
| [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) |
| Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) |
| Zometa,Zomera,Aclasta and Reclast |
| MFCD00867791 |
| [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethan-1,1-diyl]bis(phosphonsäure) |
| Zoledronic acid |
| Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid |
| (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid |
| 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid |
| [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate |
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