Fraxin

Modify Date: 2025-08-22 18:23:33

Fraxin structure	Common Name	Fraxin
	CAS Number	524-30-1	Molecular Weight	370.308
	Density	1.6±0.1 g/cm3	Boiling Point	722.2±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈O₁₀	Melting Point	205-208ºC
	MSDS	Chinese USA	Flash Point	267.1±26.4 °C

Use of Fraxin

Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].

Name	fraxin
Synonym	More Synonyms

Description	Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Natural Products >> Saccharides and Glycosides
Target	Cyclo AMP phosphodiesterase enzyme[2].
In Vitro	Fraxin (100 μM) is non-cytotoxic on Hep G2 cells. Fraxin at non-cytotoxic concentrations significantly decreases the t-BHP-induced ROS generation in a dose-dependent manner[1]. Fraxin (0.5 mM) shows free radical scavenging effect at high concentration and cell protective effect against H2O2-mediated oxidative stress[2].
In Vivo	Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].
References	[1]. Fraxin (50 mg/kg, p.o.) significantly blocks the CCl₄-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl₄-treated group^[1]. [2]. Whang WK, et al. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46.

Density	1.6±0.1 g/cm3
Boiling Point	722.2±60.0 °C at 760 mmHg
Melting Point	205-208ºC
Molecular Formula	C₁₆H₁₈O₁₀
Molecular Weight	370.308
Flash Point	267.1±26.4 °C
Exact Mass	370.089996
PSA	159.05000
LogP	-1.93
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.664
Storage condition	2-8°C

Fraxin MSDS(Chinese)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	DJ3091000

Precursor 0
DownStream 1
CAS#:574-84-5 Fraxetin

Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011)

The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components fou...

[Studies on chemical constituents from stem barks of Fraxinus paxiana].

Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008)

To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with...

[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].

Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008)

To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech...

7,8-Dihydroxy-6-methoxycoumarin-8-b-D-glucoside

7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl β-D-glucopyranoside

8-(Glucosyloxy)-6-methoxyumbelliferone

UNII-V7M270Y072

2H-1-Benzopyran-2-one, 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-

7-Hydroxy-6-méthoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2H-chromén-2-one

7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-on

8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

Fraxin

8-(b-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

Fraxoside

Fraxetin-8-O-glucoside

Fraxetin-8-glucoside

Paviin

7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl-β-D-glucopyranoside

Fraxetol 8-glucoside

7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fraxin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fraxin
Price: ￥448.0/20mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: fraxin
Price: $550.0/100mg $850.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: fraxin
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: ￥900/5 mg

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Fraxin

Use of Fraxin

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Fraxin Biological Activity

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MSDS

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Precursor & DownStream

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