524-30-1

524-30-1 structure

Name: Fraxin
Chemical Name: fraxin
CAS Number: 524-30-1
Molecular Formula: C₁₆H₁₈O₁₀
Molecular Weight: 370.308
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-07-04 14:14:41
Modify Date: 2025-08-22 18:23:33
Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].

Name	fraxin
Synonyms	7,8-Dihydroxy-6-methoxycoumarin-8-b-D-glucoside 7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl β-D-glucopyranoside 8-(Glucosyloxy)-6-methoxyumbelliferone UNII-V7M270Y072 2H-1-Benzopyran-2-one, 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy- 7-Hydroxy-6-méthoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2H-chromén-2-one 7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-on 8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one Fraxin 8-(b-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one Fraxoside Fraxetin-8-O-glucoside Fraxetin-8-glucoside Paviin 7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl-β-D-glucopyranoside Fraxetol 8-glucoside 7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one

Description	Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Natural Products >> Saccharides and Glycosides
Target	Cyclo AMP phosphodiesterase enzyme[2].
In Vitro	Fraxin (100 μM) is non-cytotoxic on Hep G2 cells. Fraxin at non-cytotoxic concentrations significantly decreases the t-BHP-induced ROS generation in a dose-dependent manner[1]. Fraxin (0.5 mM) shows free radical scavenging effect at high concentration and cell protective effect against H2O2-mediated oxidative stress[2].
In Vivo	Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].
References	[1]. Fraxin (50 mg/kg, p.o.) significantly blocks the CCl₄-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl₄-treated group^[1]. [2]. Whang WK, et al. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46.

Density	1.6±0.1 g/cm3
Boiling Point	722.2±60.0 °C at 760 mmHg
Melting Point	205-208ºC
Molecular Formula	C₁₆H₁₈O₁₀
Molecular Weight	370.308
Flash Point	267.1±26.4 °C
Exact Mass	370.089996
PSA	159.05000
LogP	-1.93
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.664
Storage condition	2-8°C

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	DJ3091000

Precursor 0
DownStream 1
574-84-5

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