Lactic acid

Modify Date: 2024-01-02 14:44:38

Lactic acid Structure
Lactic acid structure
 Common Name Lactic acid
CAS Number 50-21-5 Molecular Weight 90.078
Density 1.3±0.1 g/cm3 Boiling Point 227.6±0.0 °C at 760 mmHg
Molecular Formula C3H6O3 Melting Point 18ºC
MSDS Chinese USA Flash Point 109.9±16.3 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Lactic acid


Lactate (Lactate acid) is the product of glycolysis. Lactate is produced by oxygen lack in contracting skeletal muscle in vivo, and can be removed under fully aerobic conditions. Lactate can be as a hemodynamic marker in the critically ill[1][2].

 Names

Name 2-hydroxypropanoic acid
Synonym More Synonyms

 Lactic acid Biological Activity

Description Lactate (Lactate acid) is the product of glycolysis. Lactate is produced by oxygen lack in contracting skeletal muscle in vivo, and can be removed under fully aerobic conditions. Lactate can be as a hemodynamic marker in the critically ill[1][2].
Related Catalog
References

[1]. Brooks GA. Lactate: link between glycolytic and oxidative metabolism. Sports Med. 2007;37(4-5):341-3.

[2]. Fuller BM, et al. Lactate as a hemodynamic marker in the critically ill. Curr Opin Crit Care. 2012 Jun;18(3):267-72.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 227.6±0.0 °C at 760 mmHg
Melting Point 18ºC
Molecular Formula C3H6O3
Molecular Weight 90.078
Flash Point 109.9±16.3 °C
Exact Mass 90.031693
PSA 57.53000
LogP -0.70
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.451

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OD2800000
CHEMICAL NAME :
Lactic acid
CAS REGISTRY NUMBER :
50-21-5
LAST UPDATED :
199712
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C3-H6-O3
MOLECULAR WEIGHT :
90.09
WISWESSER LINE NOTATION :
QY1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3543 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4875 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Rectal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1810 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,195,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80595 No. of Facilities: 10707 (estimated) No. of Industries: 56 No. of Occupations: 50 No. of Employees: 68982 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80595 No. of Facilities: 10134 (estimated) No. of Industries: 39 No. of Occupations: 58 No. of Employees: 107962 (estimated) No. of Female Employees: 63436 (estimated)

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H315-H318
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;C: Corrosive;
Risk Phrases R34;R38;R41
Safety Phrases 26-39-45-36/37/39
RIDADR UN 1760
WGK Germany 2
RTECS OD2800000
Packaging Group III
Hazard Class 8
HS Code 2918110000

 Synthetic Route

2-hydroxy-3-((2-hydroxyethyl)thio)propanoic acid structure

2-hydroxy-3-((2...

CAS#:81388-05-8

~%

Lactic acid Structure

Lactic acid

CAS#:50-21-5

Lactic acid Structure

Lactic acid

CAS#:50-21-5
Literature: Kozarich, John W.; Chari, Ravi V. J. Journal of the American Chemical Society, 1982 , vol. 104, # 9 p. 2655 - 2657
N5-((2R)-1-((carboxymethyl)amino)-3-((3-(ethylthio)-2-hydroxy-3-oxopropyl)thio)-1-oxopropan-2-yl)glutamine structure

N5-((2R)-1-((ca...

CAS#:81388-02-5

~%

Lactic acid Structure

Lactic acid

CAS#:50-21-5

Lactic acid Structure

Lactic acid

CAS#:50-21-5
Literature: Kozarich, John W.; Chari, Ravi V. J. Journal of the American Chemical Society, 1982 , vol. 104, # 9 p. 2655 - 2657
Sodium 2-oxopropanoate structure

Sodium 2-oxopro...

CAS#:113-24-6

~%

Lactic acid Structure

Lactic acid

CAS#:50-21-5

Lactic acid Structure

Lactic acid

CAS#:50-21-5
Literature: Mandler, Daniel; Willner, Itamar Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 805 - 812
N5-((R)-1-((carboxymethyl)amino)-3-(((R)-2-hydroxypropanoyl)thio)-1-oxopropan-2-yl)-L-glutamine structure

N5-((R)-1-((car...

CAS#:41656-56-8

~%

Lactic acid Structure

Lactic acid

CAS#:50-21-5
Literature: Clelland, James D.; Thornalley, Paul J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3009 - 3016

 Customs

HS Code 2918110000
Summary 2918110000. lactic acid, its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Articles395

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J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...
Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

Eur. J. Pharm. Biopharm. 88(2) , 406-14, (2014)

Polycaprolactone (PCL) matrices were simultaneously loaded with the antiviral agents, tenofovir (TFV) and nevirapine (NVP), in combination to provide synergistic activity in the prevention of HIV tran...
Improved production of propionic acid in Propionibacterium jensenii via combinational overexpression of glycerol dehydrogenase and malate dehydrogenase from Klebsiella pneumoniae.

Appl. Environ. Microbiol. 81(7) , 2256-64, (2015)

Microbial production of propionic acid (PA), an important chemical building block used as a preservative and chemical intermediate, has gained increasing attention for its environmental friendliness o...

 Synonyms

2-Hydroxypropionic acid
EINECS 200-018-0
DL-Lactic acid
1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 5-bromo-a-oxo-
Lactic acid
MFCD00004520
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DL-LACTIC ACID
867-55-0
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