Arbutin

Modify Date: 2024-01-02 15:08:29

Arbutin Structure
Arbutin structure
 Common Name Arbutin
CAS Number 497-76-7 Molecular Weight 272.251
Density 1.6±0.1 g/cm3 Boiling Point 561.6±50.0 °C at 760 mmHg
Molecular Formula C12H16O7 Melting Point 195-198 °C
MSDS Chinese USA Flash Point 293.4±30.1 °C

 Use of Arbutin


Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase

 Names

Name hydroquinone O-β-D-glucopyranoside
Synonym More Synonyms

 Arbutin Biological Activity

Description Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase
Related Catalog
References

[1]. Arbutin, From Wikipedia

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 561.6±50.0 °C at 760 mmHg
Melting Point 195-198 °C
Molecular Formula C12H16O7
Molecular Weight 272.251
Flash Point 293.4±30.1 °C
Exact Mass 272.089600
PSA 119.61000
LogP -1.35
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.650
Water Solubility 10-15 g/100 mL at 20 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CE8863000
CHEMICAL NAME :
Arbutin
CAS REGISTRY NUMBER :
497-76-7
BEILSTEIN REFERENCE NO. :
0089673
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H16-O7
MOLECULAR WEIGHT :
272.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
13600 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,282,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1290 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 995 (estimated) No. of Female Employees: 745 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CE8863000
HS Code 29389090

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles36

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Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery.

Int. J. Mol. Sci. 16 , 9217-35, (2015)

The aim of this study was to investigate the effect of ethyl acetate fraction of Euryale ferox seed extracts (Efse-EA) on melanogenesis in immortalized mouse melanocyte cell line, melan-a. Efse-EA sho...
Avocado Proanthocyanidins as a Source of Tyrosinase Inhibitors: Structure Characterization, Inhibitory Activity, and Mechanism.

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Proanthocyanidins were purified from avocado (Persea americana) fruit, and their structures were analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS)...

 Synonyms

Ericolin)
4-Hydroxyphenyl β-D-glucopyranoside
Uresol
Hydroquinone-β-D-glucoside
EINECS 207-850-3
Hydroquinone-b-D-glucopyranoside
p-Hydroxyphenyl β-D-glucopyranoside
Hydroquinone-β-D-glucopyranoside
Hydroquinoneβ-D-glucopyranoside
hydroquinone O-beta-D-glucopyranoside
UVASOL
Arbutosie
MFCD00016915
P-ARBUTIN
β-D-Glucopyranoside, 4-hydroxyphenyl
4-Hydroxyphenyl-β-D-glucopyranosidep
4-Hydroxyphenyl-β-glucopyranoside
4-Hydroxyphenyl Beta-D-Glucopyranoside
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
b-Arbutin
Arbutin
4-Hydroxyphenyl-β-D-glucopyranoside
hydroquinone O-β-D-glucopyranoside
URSIN
(2R,3S,4S,5R,6S)-2-(Hydroxyméthyl)-6-(4-hydroxyphénoxy)tétrahydro-2H-pyran-3,4,5-triol
4-Hydroxyphenyl-b-D-glucopyranoside
ARBUTOSIDE
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Related Compounds: More...
Arbutin
84380-01-8
Arbutin monoester
159946-47-1
Arbutin-P-glycerol
123723-75-1
6-O-benzoyl arbutin
71202-99-8
pentaacetyl-arbutin
14698-56-7
arbutin-6-phosphoethanolamine
123723-74-0
Chemsrc provides Arbutin(CAS#:497-76-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Arbutin are included as well.>> amp version: Arbutin

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