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Arbutin

Names

[ CAS No. ]:
497-76-7

[ Name ]:
Arbutin

[Synonym ]:
Ericolin)
4-Hydroxyphenyl β-D-glucopyranoside
Uresol
Hydroquinone-β-D-glucoside
EINECS 207-850-3
Hydroquinone-b-D-glucopyranoside
p-Hydroxyphenyl β-D-glucopyranoside
Hydroquinone-β-D-glucopyranoside
Hydroquinoneβ-D-glucopyranoside
hydroquinone O-beta-D-glucopyranoside
UVASOL
Arbutosie
MFCD00016915
P-ARBUTIN
β-D-Glucopyranoside, 4-hydroxyphenyl
4-Hydroxyphenyl-β-D-glucopyranosidep
4-Hydroxyphenyl-β-glucopyranoside
4-Hydroxyphenyl Beta-D-Glucopyranoside
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
b-Arbutin
Arbutin
4-Hydroxyphenyl-β-D-glucopyranoside
hydroquinone O-β-D-glucopyranoside
URSIN
(2R,3S,4S,5R,6S)-2-(Hydroxyméthyl)-6-(4-hydroxyphénoxy)tétrahydro-2H-pyran-3,4,5-triol
4-Hydroxyphenyl-b-D-glucopyranoside
ARBUTOSIDE

Biological Activity

[Description]:

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
Natural Products >> Phenols
Research Areas >> Others

[References]

[1]. Arbutin, From Wikipedia


[Related Small Molecules]

Taxifolin | XMD 8-87 | XMD16-5 | Mulberroside A | Oxyresveratrol | Deoxyarbutin | 4-Hexylresorcinol | 4-Butylresorcinol | Glycolic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
561.6±50.0 °C at 760 mmHg

[ Melting Point ]:
195-198 °C

[ Molecular Formula ]:
C12H16O7

[ Molecular Weight ]:
272.251

[ Flash Point ]:
293.4±30.1 °C

[ Exact Mass ]:
272.089600

[ PSA ]:
119.61000

[ LogP ]:
-1.35

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Water Solubility ]:
10-15 g/100 mL at 20 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CE8863000
CHEMICAL NAME :
Arbutin
CAS REGISTRY NUMBER :
497-76-7
BEILSTEIN REFERENCE NO. :
0089673
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H16-O7
MOLECULAR WEIGHT :
272.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
13600 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,282,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1290 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 995 (estimated) No. of Female Employees: 745 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CE8863000

[ HS Code ]:
29389090

Precursor & DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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