Naphthazarin

Modify Date: 2024-01-03 16:30:31

Naphthazarin structure	Common Name	Naphthazarin
	CAS Number	475-38-7	Molecular Weight	190.15200
	Density	1.592g/cm3	Boiling Point	498.2ºC at 760mmHg
	Molecular Formula	C₁₀H₆O₄	Melting Point	220-230 °C(lit.)
	MSDS	Chinese USA	Flash Point	269.2ºC

Use of Naphthazarin

Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects[1][2].

Name	naphthazarin
Synonym	More Synonyms

Description	Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Neurological Disease
References	[1]. Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9. [2]. Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Neurological Disease

References

[1]. Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9.

[2]. Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74.

Density	1.592g/cm3
Boiling Point	498.2ºC at 760mmHg
Melting Point	220-230 °C(lit.)
Molecular Formula	C₁₀H₆O₄
Molecular Weight	190.15200
Flash Point	269.2ºC
Exact Mass	190.02700
PSA	74.60000
LogP	1.03300
Vapour Pressure	1.51E-10mmHg at 25°C
Index of Refraction	1.71

Naphthazarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL7970000

CHEMICAL NAME :: 1,4-Naphthoquinone, 5,8-dihydroxy-

CAS REGISTRY NUMBER :: 475-38-7

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H6-O4

MOLECULAR WEIGHT :: 190.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,25,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QL7970000
HS Code	2914690090

Precursor 10
CAS#:10075-68-0 1,4,5,8-tetrame... CAS#:23077-93-2 naphthalene-1,4... CAS#:14569-45-0 1,4-Naphthalene... CAS#:108-31-6 Maleic anhydride
CAS#:123-31-9 Hydroquinone CAS#:15013-16-8 1,4-Naphthalene... CAS#:64636-39-1 1,4,5-trimethox... CAS#:605-71-0 1,5-Dinitronaph...
CAS#:100012-49-5 2,3,6,7-tetrabr... CAS#:32741-27-8 5,8-dihydroxy-2...
DownStream 9
CAS#:14569-45-0 1,4-Naphthalene... CAS#:14597-06-9 5-acetoxy-8-hyd... CAS#:15013-16-8 1,4-Naphthalene... CAS#:21418-04-2 1,4-Naphthalene...
CAS#:23077-93-2 naphthalene-1,4... CAS#:81-64-1 Quinizarin CAS#:27573-16-6 1,4-dihydroxy-5... CAS#:10075-68-0 1,4,5,8-tetrame...
CAS#:100012-49-5 2,3,6,7-tetrabr...

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Stimulation of Suicidal Erythrocyte Death by Naphthazarin.

Basic Clin Pharmacol Toxicol. 117 , 369-74, (2016)

The 1,4-naphthoquinone derivative naphthazarin may trigger apoptosis and is thus considered for the treatment of malignancy. On the other hand, naphthazarin decreases neurotoxicity. In analogy to apop...

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Bioorg. Med. Chem. 17 , 2276-81, (2009)

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular ar...

Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells.

Int. J. Oncol. 46(4) , 1659-66, (2015)

Naphthazarin (Naph, DHNQ, 5,8-dihydroxy-l,4-naphthoquinone) is one of the naturally available 1,4-naphthoquinone derivatives that are well-known for their anti-inflammatory, antioxidant, antibacterial...

5,8-Dihydroxy-1,4-naphthalenedione

EINECS 207-495-4

MFCD00001685

5,8-Dihydroxy-1,4-naphthoquinone

5,8-dihydroxynaphthalene-1,4-dione

Naphthazarin

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Naphthazarin
Price: ￥1148.0/1g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Naphthazarin
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,8-Dihydroxy-1,4-naphthoquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: naphthazarin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥750/100 mg

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Naphthazarin

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