Lactulose structure
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Common Name | Lactulose | ||
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CAS Number | 4618-18-2 | Molecular Weight | 342.297 | |
Density | 1.32 g/cm3 | Boiling Point | 680.5±55.0 °C at 760 mmHg | |
Molecular Formula | C12H22O11 | Melting Point | ~169 °C (dec.) | |
MSDS | USA | Flash Point | 365.4±31.5 °C |
Use of LactuloseLactulose is a non-absortable sugar used in the treatment of constipation and hepatic encephalopathy. It generally begin working after eight to twelve hours but may take up to two days to improve constipation. |
Name | lactulose |
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Synonym | More Synonyms |
Description | Lactulose is a non-absortable sugar used in the treatment of constipation and hepatic encephalopathy. It generally begin working after eight to twelve hours but may take up to two days to improve constipation. |
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Related Catalog |
Density | 1.32 g/cm3 |
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Boiling Point | 680.5±55.0 °C at 760 mmHg |
Melting Point | ~169 °C (dec.) |
Molecular Formula | C12H22O11 |
Molecular Weight | 342.297 |
Flash Point | 365.4±31.5 °C |
Exact Mass | 342.116211 |
PSA | 197.37000 |
LogP | -3.21 |
Vapour Pressure | 0.0±4.8 mmHg at 25°C |
Index of Refraction | 1.656 |
Water Solubility | 76.4 G/100 ML (30 ºC) |
Synonym:4-Ortho-Beta-D-Galactopyranosyl-D-Fructose; Isolactos Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause irritation of the digestive tract. Low hazard for usual industrial handling. Inhalation: May cause respiratory tract irritation. Low hazard for usual industrial handling. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Get medical aid if irritation or symptoms occur. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. No special precautions indicated. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 4618-18-2: CAS# 7732-18-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: clear light yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 173.00 - 178.00 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: 76.4% (30 c) Specific Gravity/Density: Molecular Formula: C12H22O11 Molecular Weight: 342.28 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 4618-18-2: LS6965000 CAS# 7732-18-5: ZC0110000 LD50/LC50: CAS# 4618-18-2: Oral, mouse: LD50 = 31 gm/kg; Oral, rat: LD50 = 18160 mg/kg. CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg. Carcinogenicity: D-Fructose, 4-O-Beta-D-Galactopyranosyl- - Not listed by ACGIH, IARC, or NTP. Water - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 4618-18-2: No information available. CAS# 7732-18-5: No information available. Canada CAS# 4618-18-2 is listed on Canada's DSL List. CAS# 7732-18-5 is listed on Canada's DSL List. CAS# 4618-18-2 is not listed on Canada's Ingredient Disclosure List. CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 4618-18-2 is listed on the TSCA inventory. CAS# 7732-18-5 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~% Lactulose CAS#:4618-18-2 |
Literature: Vera, Carlos; Guerrero, Cecilia; Illanes, Andres Carbohydrate Research, 2011 , vol. 346, # 6 p. 745 - 752 |
~% Lactulose CAS#:4618-18-2 |
Literature: Song, Yoon-Seok; Lee, Hee-Uk; Park, Chulhwan; Kim, Seung-Wook Carbohydrate Research, 2013 , vol. 369, p. 1 - 5 |
~% Lactulose CAS#:4618-18-2 |
Literature: Guerrero, Cecilia; Vera, Carlos; Plou, Francisco; Illanes, Andres Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 72, # 3-4 p. 206 - 212 |
~% Lactulose CAS#:4618-18-2 |
Literature: Bots Recueil des Travaux Chimiques des Pays-Bas, 1957 , vol. 76, p. 515,516 Full Text Show Details Kuhn; Krueger Justus Liebigs Annalen der Chemie, 1959 , vol. 628, p. 240,250 Anm. 28 a |
Precursor 3 | |
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DownStream 0 |
Substrates specialization in lipid compounds and hydrocarbons of Marinobacter genus.
Environ. Sci. Pollut. Res. Int. 22 , 15347-59, (2015) The impact of petroleum contamination and of burrowing macrofauna on abundances of Marinobacter and denitrifiers was tested in marine sediment mesocoms after 3 months incubation. Quantification of thi... |
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Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: use of time course analysis to optimize its use to assess regional gut permeability.
Clin. Chim. Acta 442 , 24-32, (2015) Measurement of intestinal permeability is important in several diseases but currently several methods are employed. We sought to: (1) develop a new GC based method to measure urinary mannitol, lactulo... |
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Improvement of efficiency in the enzymatic synthesis of lactulose palmitate.
J. Agric. Food Chem. 63(14) , 3716-24, (2015) Sugar esters are considered as surfactants due to its amphiphilic balance that can lower the surface tension in oil/water mixtures. Enzymatic syntheses of these compounds are interesting both from eco... |
laevolac |
(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxyméthyl)tétrahydrofuran-3-yl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol |
MFCD00151469 |
Lactulose |
Cholac |
Enulose |
Liforos |
4-O-β-D-Galactopyranosyl-β-D-fructofuranose |
Caloryl |
4-D-Galactopyranosyl-4-D-fructofuranose |
cephulac |
(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxyméthyl)tétrahydro-3-furanyl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol |
MLS-50 |
4-b-d-galactosido-d-fructose |
EINECS 225-027-7 |
4-O-β-δ-Galactopyranosyl-δ-fructose |
β-D-Fructofuranose, 4-O-β-D-galactopyranosyl- |
Lagnos |
(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydro-3-furanyl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
4-O-b-D-Galactosyl-D-fructose |
Duphalac |
Piarle |
(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
4-O-β-D-Galactopyranosyl-D-fructofuranose |