SOS1-IN-1

Modify Date: 2024-01-11 19:45:15

Use of SOS1-IN-1

SOS1-IN-1 is a SOS1 inhibitor.

Name	9-[3-(2-nitrophenyl)prop-2-enylidene]fluorene

Description	SOS1-IN-1 is a SOS1 inhibitor.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	SOS1[1].
In Vitro	The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].
Cell Assay	MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].
References	[1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.

9H FLUORENE

CAS#:86-73-7

o-Nitrocinnamal...

CAS#:1466-88-2

SOS1-IN-1

CAS#:4551-00-2

Literature: Kuhn; Winterstein Helvetica Chimica Acta, 1928 , vol. 11, p. 113 Helvetica Chimica Acta, 1929 , vol. 12, p. 493

Precursor 2
CAS#:86-73-7 9H FLUORENE CAS#:1466-88-2 o-Nitrocinnamal...
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