NSC 185058
Modify Date: 2025-08-25 21:44:07
NSC 185058 structure
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Common Name | NSC 185058 | ||
|---|---|---|---|---|
| CAS Number | 39122-38-8 | Molecular Weight | 215.27400 | |
| Density | 1.323g/cm3 | Boiling Point | 378.2ºC at 760 mmHg | |
| Molecular Formula | C11H9N3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 182.5ºC | |
Use of NSC 185058NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1]. |
| Name | N-pyridin-2-ylpyridine-2-carbothioamide |
|---|---|
| Synonym | More Synonyms |
| Description | NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1]. |
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| Related Catalog | |
| Target |
Autophagy[1] |
| In Vitro | NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1]. |
| References |
| Density | 1.323g/cm3 |
|---|---|
| Boiling Point | 378.2ºC at 760 mmHg |
| Molecular Formula | C11H9N3S |
| Molecular Weight | 215.27400 |
| Flash Point | 182.5ºC |
| Exact Mass | 215.05200 |
| PSA | 69.90000 |
| LogP | 2.33720 |
| Index of Refraction | 1.72 |
| Storage condition | 2-8℃ |
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~%
NSC 185058 CAS#:39122-38-8 |
| Literature: Lions; Martin Journal of the American Chemical Society, 1958 , vol. 80, p. 1591 Full Text View citing articles Show Details Saikachi; Hisano Chem. pharm., Bl. 7 <1959> 349, 354, 355 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 2-Pyridinecarbothioamide,N-2-pyridinyl |
| pyridine-2-carbothioic acid pyridin-2-ylamide |
| pyridine-2-carbothioic acid-[2]pyridylamide |
| Pyridin-2-thiocarbonsaeure-[2]pyridylamid |
| N-(2-pyridyl)pyridine-2-thiocarboxamide |
| N-2-Pyridylthiopicolinamid |
| Thiopicolinsaeureamid-(2-pyridyl) |