39122-38-8
39122-38-8 structure
- Name: NSC 185058
- Chemical Name: N-pyridin-2-ylpyridine-2-carbothioamide
- CAS Number: 39122-38-8
- Molecular Formula: C11H9N3S
- Molecular Weight: 215.27400
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2016-08-18 13:05:46
- Modify Date: 2025-08-25 21:44:07
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NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].
| Name | N-pyridin-2-ylpyridine-2-carbothioamide |
|---|---|
| Synonyms |
2-Pyridinecarbothioamide,N-2-pyridinyl
pyridine-2-carbothioic acid pyridin-2-ylamide pyridine-2-carbothioic acid-[2]pyridylamide Pyridin-2-thiocarbonsaeure-[2]pyridylamid N-(2-pyridyl)pyridine-2-thiocarboxamide N-2-Pyridylthiopicolinamid Thiopicolinsaeureamid-(2-pyridyl) |
| Description | NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Autophagy[1] |
| In Vitro | NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1]. |
| References |
| Density | 1.323g/cm3 |
|---|---|
| Boiling Point | 378.2ºC at 760 mmHg |
| Molecular Formula | C11H9N3S |
| Molecular Weight | 215.27400 |
| Flash Point | 182.5ºC |
| Exact Mass | 215.05200 |
| PSA | 69.90000 |
| LogP | 2.33720 |
| Index of Refraction | 1.72 |
| Storage condition | 2-8℃ |
|
~%
39122-38-8 |
| Literature: Lions; Martin Journal of the American Chemical Society, 1958 , vol. 80, p. 1591 Full Text View citing articles Show Details Saikachi; Hisano Chem. pharm., Bl. 7 <1959> 349, 354, 355 |
