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144678-63-7

144678-63-7 structure
144678-63-7 structure
  • Name: NSC 668036
  • Chemical Name: 9,15-diisopropyl-2,2,6,12-tetramethyl-4,7,10,13-tetraoxo-3,8,14-trioxa-5,11-diazahexadecan-16-oic acid
  • CAS Number: 144678-63-7
  • Molecular Formula: C21H36N2O9
  • Molecular Weight: 460.51900
  • Catalog: Signaling Pathways Stem Cell/Wnt Wnt
  • Create Date: 2017-07-20 19:23:46
  • Modify Date: 2025-09-07 09:42:04
  • NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

Name 9,15-diisopropyl-2,2,6,12-tetramethyl-4,7,10,13-tetraoxo-3,8,14-trioxa-5,11-diazahexadecan-16-oic acid
Synonyms nsc 668036 hydrate
NSC 668036
Description NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].
Related Catalog
In Vitro In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1]. NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2].
In Vivo In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2].
References

[1]. Jufang Shan, et al. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry. 2005 Nov 29;44(47):15495-503.

[2]. Cong Wang, et al. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp Cell Res. 2015 Feb 1;331(1):115-122.

Molecular Formula C21H36N2O9
Molecular Weight 460.51900
Exact Mass 460.24200
PSA 157.33000
LogP 2.40630
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