144678-63-7

144678-63-7 structure

Name: NSC 668036
Chemical Name: 9,15-diisopropyl-2,2,6,12-tetramethyl-4,7,10,13-tetraoxo-3,8,14-trioxa-5,11-diazahexadecan-16-oic acid
CAS Number: 144678-63-7
Molecular Formula: C₂₁H₃₆N₂O₉
Molecular Weight: 460.51900
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2017-07-20 19:23:46
Modify Date: 2025-09-07 09:42:04
NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

Name	9,15-diisopropyl-2,2,6,12-tetramethyl-4,7,10,13-tetraoxo-3,8,14-trioxa-5,11-diazahexadecan-16-oic acid
Synonyms	nsc 668036 hydrate NSC 668036

Description	NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Inflammation/Immunology
In Vitro	In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1]. NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2].
In Vivo	In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2].
References	[1]. Jufang Shan, et al. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry. 2005 Nov 29;44(47):15495-503. [2]. Cong Wang, et al. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp Cell Res. 2015 Feb 1;331(1):115-122.