NSC 185058

Names

[ Name ]:
NSC 185058

[Synonym ]:
2-Pyridinecarbothioamide,N-2-pyridinyl
pyridine-2-carbothioic acid pyridin-2-ylamide
pyridine-2-carbothioic acid-[2]pyridylamide
Pyridin-2-thiocarbonsaeure-[2]pyridylamid
N-(2-pyridyl)pyridine-2-thiocarboxamide
N-2-Pyridylthiopicolinamid
Thiopicolinsaeureamid-(2-pyridyl)

Biological Activity

[Description]:

NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[Target]

Autophagy[1]

[In Vitro]

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

[References]

[1]. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.

Chemical & Physical Properties

[ Density]:
1.323g/cm3

[ Boiling Point ]:
378.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₉N₃S

[ Molecular Weight ]:
215.27400

[ Flash Point ]:
182.5ºC

[ Exact Mass ]:
215.05200

[ PSA ]:
69.90000

[ LogP ]:
2.33720

[ Index of Refraction ]:
1.72

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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