NSC 131114

Names

[ Name ]:
NSC 131114

[Synonym ]:
S-Hexylglutathione
MFCD00056735

Biological Activity

[Description]:

S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

S-Hexylglutathione is bound by human glutathione transferase P1-1 with Kd values of 3.7 μM (Y49F mutant) and 1.27 μM (wild-type), respectively[1].

Chemical & Physical Properties

[ Density]:
1.254g/cm3

[ Boiling Point ]:
748.5ºC at 760 mmHg

[ Melting Point ]:
200-202ºC(lit.)

[ Molecular Formula ]:
C₁₆H₂₉N₃O₆S

[ Molecular Weight ]:
391.48300

[ Flash Point ]:
406.5ºC

[ Exact Mass ]:
391.17800

[ PSA ]:
184.12000

[ LogP ]:
1.65970

[ Vapour Pressure ]:
1.61E-24mmHg at 25°C

[ Index of Refraction ]:
1.54

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Quantitation of protein S-glutathionylation by liquid chromatography-tandem mass spectrometry: correction for contaminating glutathione and glutathione disulfide.

Anal. Biochem. 469 , 54-64, (2014)

Protein S-glutathionylation is a posttranslational modification that links oxidative stimuli to reversible changes in cellular function. Protein-glutathione mixed disulfide (PSSG) is commonly quantifi...

Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma.

Eur. J. Pharmacol. 765 , 242-8, (2015)

We assessed in this study the anti-asthmatic effects of ONO-6950, a novel cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors dual antagonist, in normal and S-hexyl glutathione (S-hexyl GSH)-tre...

Glutathionylation and Reduction of Methacrolein in Tomato Plants Account for Its Absorption from the Vapor Phase.

Plant Physiol. 169 , 1744-54, (2015)

A large portion of the volatile organic compounds emitted by plants are oxygenated to yield reactive carbonyl species, which have a big impact on atmospheric chemistry. Deposition to vegetation driven...