SIA Crosslinker
SIA Crosslinker structure
|
Common Name | SIA Crosslinker | ||
|---|---|---|---|---|
| CAS Number | 39028-27-8 | Molecular Weight | 283.021 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 315.6±44.0 °C at 760 mmHg | |
| Molecular Formula | C6H6INO4 | Melting Point | 148ºC | |
| MSDS | Chinese USA | Flash Point | 144.7±28.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SIA CrosslinkerSIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
| Name | iodoacetic acid n-hydroxysuccinimide ester |
|---|---|
| Synonym | More Synonyms |
| Description | SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 315.6±44.0 °C at 760 mmHg |
| Melting Point | 148ºC |
| Molecular Formula | C6H6INO4 |
| Molecular Weight | 283.021 |
| Flash Point | 144.7±28.4 °C |
| Exact Mass | 282.934143 |
| PSA | 63.68000 |
| LogP | -0.76 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.615 |
| InChIKey | VRDGQQTWSGDXCU-UHFFFAOYSA-N |
| SMILES | O=C(CI)ON1C(=O)CCC1=O |
| Storage condition | −20°C |
| Water Solubility | DMF: 50 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
|
~29%
SIA Crosslinker CAS#:39028-27-8 |
| Literature: Marco Colas, Maria Pilar; Sánchez Baeza, Francisco José; González Pinacho, Daniel Patent: US2013/273581 A1, 2013 ; Location in patent: Page/Page column 0092; 0111-0112; 0114 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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A method for the preparation of protein-protein conjugates of predetermined composition.
J. Immunol. Methods 24 , 321-336, (1978) A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reacti... |
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Conjugation to preactivated proteins using divinylsulfone and iodoacetic acid.
J. Immunol. Methods 181 , 187-200, (1995) Two methods for the preactivation of proteins and conjugation of peptides to proteins under mild conditions are presented. Preactivation of proteins with divinylsulfone (DVS) permits peptide conjugati... |
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Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.
ACS Nano 7 , 9001-9, (2013) Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with nu... |
| 1-(2-Iodoacetoxy)-2,5-pyrrolidinedione |
| N-SucciniMidyl Iodoacetate |
| 2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]- |
| N-(Iodoacetoxy)succinimide |
| 1-(2-Iodoacetoxy)pyrrolidine-2,5-dione |
| Iodoacetic Acid N-Succinimidyl Ester |
| (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate |
| N-Succinimidyl iodoacetate(SIA) |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SIA Crosslinker
- Price: Check
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: SIA Crosslinker
- Price: ￥648.0/25mg ￥1818.0/100mg
- Purity: 95.0%
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- DC Chemicals Limited
- China
- Product Name: SIA Crosslinker
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- China
- Product Name: N-SUCCINIMIDYL IODOACETATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
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- Email: enquiry@dycnchem.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: SIA Crosslinker
- Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/1mg ￥Inquiry/250mg
- Purity: 95.0%
- Delivery: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
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