DSG Crosslinker
Modify Date: 2024-01-04 22:11:29
DSG Crosslinker structure
|
Common Name | DSG Crosslinker | ||
|---|---|---|---|---|
| CAS Number | 79642-50-5 | Molecular Weight | 326.259 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 485.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C13H14N2O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 247.2±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of DSG CrosslinkerDSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
| Name | bis(2,5-dioxopyrrolidin-1-yl) pentanedioate |
|---|---|
| Synonym | More Synonyms |
| Description | DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.1±55.0 °C at 760 mmHg |
| Molecular Formula | C13H14N2O8 |
| Molecular Weight | 326.259 |
| Flash Point | 247.2±31.5 °C |
| Exact Mass | 326.075012 |
| PSA | 127.36000 |
| LogP | -3.30 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.572 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
|
~99%
DSG Crosslinker CAS#:79642-50-5 |
| Literature: Van Den Berg, Tieme A.; Feringa, Ben L.; Roelfes, Gerard Chemical Communications, 2007 , # 2 p. 180 - 182 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
|
New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.
Biochimie 118 , 1-7, (2015) The eukaryotic translation elongation factor 1A (eEF1A) is a moonlighting protein that besides to its canonical role in protein synthesis is also involved in many other cellular processes such as cell... |
|
|
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
Nat. Commun. 6 , 6285, (2015) STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that S... |
|
|
The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.
Sci. Rep. 5 , 9059, (2015) The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the role of Nr4a1 in CD8(+) T... |
| N,N'-disuccinimidyl glutarate |
| 1,1'-[(1,5-Dioxo-1,5-pentanediyl)bis(oxy)]di(2,5-pyrrolidinedione) |
| DISUCCINIMIDYL GLUTARATE |
| 2,5-Pyrrolidinedione, 1,1'-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis- |
| N-hydroxysuccinimide ester disuccinimidyl glutarate |