SIA Crosslinker
Names
[ CAS No. ]:
39028-27-8
[ Name ]:
SIA Crosslinker
[Synonym ]:
1-(2-Iodoacetoxy)-2,5-pyrrolidinedione
N-SucciniMidyl Iodoacetate
2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]-
N-(Iodoacetoxy)succinimide
1-(2-Iodoacetoxy)pyrrolidine-2,5-dione
Iodoacetic Acid N-Succinimidyl Ester
(2,5-dioxopyrrolidin-1-yl) 2-iodoacetate
N-Succinimidyl iodoacetate(SIA)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Non-cleavable
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
2.1±0.1 g/cm3
[ Boiling Point ]:
315.6±44.0 °C at 760 mmHg
[ Melting Point ]:
148ºC
[ Molecular Formula ]:
C6H6INO4
[ Molecular Weight ]:
283.021
[ Flash Point ]:
144.7±28.4 °C
[ Exact Mass ]:
282.934143
[ PSA ]:
63.68000
[ LogP ]:
-0.76
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.615
[ Storage condition ]:
−20°C
[ Water Solubility ]:
DMF: 50 mg/mL
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
J. Immunol. Methods 24 , 321-336, (1978)
A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reacti...
Conjugation to preactivated proteins using divinylsulfone and iodoacetic acid.J. Immunol. Methods 181 , 187-200, (1995)
Two methods for the preactivation of proteins and conjugation of peptides to proteins under mild conditions are presented. Preactivation of proteins with divinylsulfone (DVS) permits peptide conjugati...
Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.ACS Nano 7 , 9001-9, (2013)
Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with nu...