BS3 Crosslinker

Names

[ Name ]:
BS3 Crosslinker

[Synonym ]:
Bis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS))
3-Pyrrolidinesulfonic acid, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis[2,5-dioxo-, sodium salt (1:1)
BS(3) Cpd
MFCD00054982
1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis(2,5-dioxo-3-pyrrolidinesulfonic acid)
Bis(sulfosuccinimidyl) suberate sodium salt
BSSIS
bis(sulfosuccinimidyl)suberate
Disulfosuccinimidyl suberate
Sodium 1-({8-[(2,5-dioxo-3-sulfo-1-pyrrolidinyl)oxy]-8-oxooctanoyl}oxy)-2,5-dioxo-3-pyrrolidinesulfonate

Biological Activity

[Description]:

BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₁₆H₂₀N₂O₁₄S₂

[ Molecular Weight ]:
550.447

[ Exact Mass ]:
550.017517

[ PSA ]:
255.69000

[ Appearance of Characters ]:
powder

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

Articles

Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor.

PLoS ONE 10(3) , e0120162, (2015)

Aberrant glycosylation changes normal cellular functions and represents a specific hallmark of cancer. Lewisy (Ley) carbohydrate upregulation has been reported in a variety of cancers, including oral ...

Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish.

PLoS ONE 10 , e0126388, (2015)

Toll-like receptor 9 (TLR9) recognizes and binds unmethylated CpG motifs in DNA, which are found in the genomes of bacteria and DNA viruses. In fish, Tlr9 is highly diverse, with the number of introns...

Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure.

Nucleic Acids Res. 43 , 3033-45, (2015)

Despite insights on the cellular level, the molecular details of chromatin reorganization in sperm development, which involves replacement of histone proteins by specialized factors to allow ultra mos...