82436-77-9
82436-77-9 structure
- Name: BS3 Crosslinker
- Chemical Name: 1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid
- CAS Number: 82436-77-9
- Molecular Formula: C16H20N2O14S2
- Molecular Weight: 550.447
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-09-17 18:57:11
- Modify Date: 2025-08-25 13:10:26
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BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | 1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid |
|---|---|
| Synonyms |
Bis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS))
3-Pyrrolidinesulfonic acid, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis[2,5-dioxo-, sodium salt (1:1) BS(3) Cpd MFCD00054982 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis(2,5-dioxo-3-pyrrolidinesulfonic acid) Bis(sulfosuccinimidyl) suberate sodium salt BSSIS bis(sulfosuccinimidyl)suberate Disulfosuccinimidyl suberate Sodium 1-({8-[(2,5-dioxo-3-sulfo-1-pyrrolidinyl)oxy]-8-oxooctanoyl}oxy)-2,5-dioxo-3-pyrrolidinesulfonate |
| Description | BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Melting Point | >300°C |
|---|---|
| Molecular Formula | C16H20N2O14S2 |
| Molecular Weight | 550.447 |
| Exact Mass | 550.017517 |
| PSA | 255.69000 |
| Appearance | powder |
| Storage condition | −20°C |
| Water Solubility | H2O: 10 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | - |