CK869

Modify Date: 2025-08-25 17:44:15

Use of CK869

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

Name	2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one

Description	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Cancer
Target	IC50: 7 μM (ARP2/3)[1].
In Vitro	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].
References	[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12. [2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.

Molecular Formula	C₁₇H₁₆BrNO₃S
Molecular Weight	394.28300
Exact Mass	393.00300
PSA	64.07000
LogP	4.30990
InChIKey	MVWNPZYLNLATCH-UHFFFAOYSA-N
SMILES	COc1ccc(N2C(=O)CSC2c2cccc(Br)c2)c(OC)c1
Storage condition	2-8℃

CK869 MSDS(Chinese)

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Price: ￥990/10 mM * 1 mL in DMSO

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