CK869

Names

[ CAS No. ]:
388592-44-7

[ Name ]:
CK869

Biological Activity

[Description]:

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex

Research Areas >> Cancer

[Target]

IC50: 7 μM (ARP2/3)[1].

[In Vitro]

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].

[References]

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

[2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.

[Related Small Molecules]

CK-636 | Cytochalasin B

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₆BrNO₃S

[ Molecular Weight ]:
394.28300

[ Exact Mass ]:
393.00300

[ PSA ]:
64.07000

[ LogP ]:
4.30990

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds

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