388592-44-7

388592-44-7 structure

Name: CK869
Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one
CAS Number: 388592-44-7
Molecular Formula: C₁₇H₁₆BrNO₃S
Molecular Weight: 394.28300
Catalog: Signaling Pathways Cytoskeleton Arp2/3 Complex
Create Date: 2017-10-31 08:18:26
Modify Date: 2024-01-11 00:14:51
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

Name	2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one

Description	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Cancer
Target	IC50: 7 μM (ARP2/3)[1].
In Vitro	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].
References	[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12. [2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.