187-1, N-WASP inhibitor TFA

Modify Date: 2025-08-24 09:35:06

187-1, N-WASP inhibitor TFA structure	Common Name	187-1, N-WASP inhibitor TFA
	CAS Number	380488-27-7	Molecular Weight	1784.11000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉₆H₁₂₂N₁₈O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 187-1, N-WASP inhibitor TFA

187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].

Name	187-1, N-WASP inhibitor
Synonym	More Synonyms

Description	187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Others
References	[1]. Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. [2]. S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J Biol Chem. 2001 Aug 31;276(35):33175-80.

Description

Related Catalog

Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex

Research Areas >> Others

References

[1]. Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9.

[2]. S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J Biol Chem. 2001 Aug 31;276(35):33175-80.

Molecular Formula	C₉₆H₁₂₂N₁₈O₁₆
Molecular Weight	1784.11000
Exact Mass	1782.93000
PSA	510.46000
LogP	6.89800
InChIKey	PHTIQAVQWWOKNF-RNEDXEELSA-N
SMILES	NCCCCC1NC(=O)C(CCC(N)=O)NC(=O)C2CCCN2C(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C2CCCN2C(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C2CCCN2C(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C2CCCN2C(=O)C(Cc2ccccc2)NC1=O

Hazard Codes	Xi

n-wasp-inhibitor,187-1

m.w. 1784.13 c96h122n18o16

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 187-1, N-WASP inhibitor TFA
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 187-1, N-WASP inhibitor
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 187-1, N-WASP INHIBITOR
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.