10,11-Dihydrocarbamazepine

Modify Date: 2024-01-03 18:11:42

10,11-Dihydrocarbamazepine structure	Common Name	10,11-Dihydrocarbamazepine
	CAS Number	3564-73-6	Molecular Weight	238.28
	Density	1.2±0.1 g/cm3	Boiling Point	394.5±52.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄N₂O	Melting Point	205-210ºC
	MSDS	Chinese USA	Flash Point	192.4±30.7 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of 10,11-Dihydrocarbamazepine

10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].

Name	5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
Synonym	More Synonyms

Description	10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1].
References	[1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33.

Density	1.2±0.1 g/cm3
Boiling Point	394.5±52.0 °C at 760 mmHg
Melting Point	205-210ºC
Molecular Formula	C₁₅H₁₄N₂O
Molecular Weight	238.28
Flash Point	192.4±30.7 °C
Exact Mass	238.110611
PSA	46.33000
LogP	2.60
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.645
Storage condition	Refrigerator
Water Solubility	dichloromethane: soluble2.5%, clear, colorless \| Soluble in dichloromethane. Insoluble in water.

10,11-Dihydrocarbamazepine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HN8300000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-

CAS REGISTRY NUMBER :: 3564-73-6

BEILSTEIN REFERENCE NO. :: 0196969

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H14-N2-O

MOLECULAR WEIGHT :: 238.31

WISWESSER LINE NOTATION :: T C676 BN&T&J BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Hazard Codes	Xn
Risk Phrases	22-42/43
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HN8300000
HS Code	2933990090

IMINODIBENZYL C...

CAS#:33948-19-5

~84%

10,11-Dihydroca...

CAS#:3564-73-6

Literature: Shamshin, V. P.; Voronin, V. G.; Borisov, M. M.; Mufazalova, T. P. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 6 p. 711 - 716

Carbamazepine

CAS#:298-46-4

~85%

10,11-Dihydroca...

CAS#:3564-73-6

Literature: Dunnbier; Jugelt Pharmazie, 1991 , vol. 46, # 7 p. 512 - 517

Iminodibenzyl

CAS#:494-19-9

10,11-Dihydroca...

CAS#:3564-73-6

Literature: Pharmaceutical Chemistry Journal, , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 6 p. 711 - 716

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

Eur. J. Biochem. 267(1) , 110-20, (2000)

Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the str...

Liquid chromatographic methods for assay of carbamazepine, 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets.

J. Assoc. Off. Anal. Chem. 70(5) , 836-40, (1987)

Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and table...

An orthorhombic polymorph of 10,11-dihydrocarbamazepine.

Acta Crystallogr. C 62(Pt 5) , o240-2, (2006)

The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The mo...

10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine

10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin

10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine

GP 26-301

10,11-DIHYDROCARBAMAZEPINE

EINECS 222-649-0

10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide

10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide

MFCD00005072

10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide

10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO

5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 10,11-Dihydrocarbamazepine
Price: ￥818.0/100mg ￥348.0/25mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 10,11-Dihydrocarbamazepine
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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