3564-73-6

3564-73-6 structure

Name: 10,11-Dihydrocarbamazepine
Chemical Name: 5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
CAS Number: 3564-73-6
Molecular Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-09-27 13:13:47
Modify Date: 2024-01-03 18:11:42
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].

Name	5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
Synonyms	10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine GP 26-301 10,11-DIHYDROCARBAMAZEPINE EINECS 222-649-0 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide 10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide MFCD00005072 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide 5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-

Description	10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1].
References	[1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33.

Density	1.2±0.1 g/cm3
Boiling Point	394.5±52.0 °C at 760 mmHg
Melting Point	205-210ºC
Molecular Formula	C₁₅H₁₄N₂O
Molecular Weight	238.28
Flash Point	192.4±30.7 °C
Exact Mass	238.110611
PSA	46.33000
LogP	2.60
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.645
Storage condition	Refrigerator
Water Solubility	dichloromethane: soluble2.5%, clear, colorless \| Soluble in dichloromethane. Insoluble in water.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Hazard Codes	Xn
Risk Phrases	22-42/43
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HN8300000
HS Code	2933990090

33948-19-5

~84%

3564-73-6

298-46-4

~85%

3564-73-6

Literature: Dunnbier; Jugelt Pharmazie, 1991 , vol. 46, # 7 p. 512 - 517

494-19-9

3564-73-6

Literature: Pharmaceutical Chemistry Journal, , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 6 p. 711 - 716

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%