Mecillinam
Modify Date: 2024-01-02 10:38:54
Mecillinam structure
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Common Name | Mecillinam | ||
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| CAS Number | 32887-01-7 | Molecular Weight | 439.569 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 581.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H23N3O3S | Melting Point | 156°C | |
| MSDS | Chinese USA | Flash Point | 305.2±32.9 °C | |
Use of MecillinamMecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1]. |
| Name | mecillinam |
|---|---|
| Synonym | More Synonyms |
| Description | Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1]. |
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| Related Catalog | |
| In Vivo | Mecillinam (Amdinocillin, 400 mg per kg) is effective for the treatment of catheterassociated infections at high dosages (400 mg per kg of body weight/d)[1]. Animal Model: Mecillinam (Amdinocillin, 400 mg per kg) is effective for the treatment of catheterassociated infections at high dosages (400 mg per kg of body weight/d)[1]. Dosage: 50, 100, 200, and 400 mg per kg. Administration: Intravenously each day in four divided doses over a 72-h period. Result: High dose of 400 mg/kg exhibited significant activity. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 581.0±60.0 °C at 760 mmHg |
| Melting Point | 156°C |
| Molecular Formula | C15H23N3O3S |
| Molecular Weight | 439.569 |
| Flash Point | 305.2±32.9 °C |
| Exact Mass | 439.214081 |
| PSA | 98.51000 |
| LogP | 2.97 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.604 |
| Storage condition | Store at?0-5°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Mecillinam CAS#:32887-01-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 35, # 2 p. 642 - 646 |
| Precursor 2 | |
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| DownStream 0 | |
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Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.
Anal. Biochem. 463 , 15-22, (2014) High-molecular-weight penicillin-binding proteins (PBPs) are essential integral membrane proteins of the bacterial cytoplasmic membrane responsible for biosynthesis of peptidoglycan. They are the targ... |
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The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistance.
J. Bacteriol. 190(6) , 2065-74, (2008) Gram-negative bacteria possess stress responses to maintain the integrity of the cell envelope. Stress sensors monitor outer membrane permeability, envelope protein folding, and energization of the in... |
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The bacterial actin MreB rotates, and rotation depends on cell-wall assembly.
Proc. Natl. Acad. Sci. U. S. A. 108(38) , 15822-7, (2011) Bacterial cells possess multiple cytoskeletal proteins involved in a wide range of cellular processes. These cytoskeletal proteins are dynamic, but the driving forces and cellular functions of these d... |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E)-(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (5R,6R)- |
| [(2,2-Dimethylpropanoyl)oxy]methyl (5R,6R)-6-[(E)-(1-azepanylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amdinocillin |
| Mecillinam |
| EINECS 251-277-1 |
| MFCD00056869 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Mecillinam
- Price: ￥1758.0/100mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Mecillinam
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Mecillinam
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
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Price: ￥819/5g
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