Mecillinam
Mecillinam structure
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Common Name | Mecillinam | ||
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| CAS Number | 32887-01-7 | Molecular Weight | 439.569 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 581.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H23N3O3S | Melting Point | 156°C | |
| MSDS | Chinese USA | Flash Point | 305.2±32.9 °C | |
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Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.
Anal. Biochem. 463 , 15-22, (2014) High-molecular-weight penicillin-binding proteins (PBPs) are essential integral membrane proteins of the bacterial cytoplasmic membrane responsible for biosynthesis of peptidoglycan. They are the targets of antibacterial β-lactam drugs, including penicillins,... |
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The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistance.
J. Bacteriol. 190(6) , 2065-74, (2008) Gram-negative bacteria possess stress responses to maintain the integrity of the cell envelope. Stress sensors monitor outer membrane permeability, envelope protein folding, and energization of the inner membrane. The systems used by gram-negative bacteria to... |
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The bacterial actin MreB rotates, and rotation depends on cell-wall assembly.
Proc. Natl. Acad. Sci. U. S. A. 108(38) , 15822-7, (2011) Bacterial cells possess multiple cytoskeletal proteins involved in a wide range of cellular processes. These cytoskeletal proteins are dynamic, but the driving forces and cellular functions of these dynamics remain poorly understood. Eukaryotic cytoskeletal d... |
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Mecillinam resistance and outcome of pivmecillinam treatment in uncomplicated lower urinary tract infection in women.
APMIS 122(4) , 317-23, (2014) Pivmecillinam (PIV) is a first-line antimicrobial for treatment of lower urinary tract infection in women (LUTIW). Mecillinam, the active substance of PIV, is bactericidal mainly against gram-negative uropathogens, whereas gram-positive species are considered... |
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Activity of mecillinam against ESBL producers in vitro.
J. Antimicrob. Chemother. 57(2) , 367-8, (2006)
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Mecillinam has potent in vitro activity against Chlamydophila pneumoniae ATCC VR1310.
J. Antimicrob. Chemother. 53(6) , 1112, (2004)
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Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins.
J. Antimicrob. Chemother. 65(1) , 79-81, (2010) To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined beta-lactamases; and (ii) isolates resistant to third-generation cephalospor... |
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Growth of Escherichia coli: significance of peptidoglycan degradation during elongation and septation.
J. Bacteriol. 190(11) , 3914-22, (2008) We have found a striking difference between the modes of action of amdinocillin (mecillinam) and compound A22, both of which inhibit cell elongation. This was made possible by employment of a new method using an Escherichia coli peptidoglycan (PG)-recycling m... |
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Caulobacter crescentus requires RodA and MreB for stalk synthesis and prevention of ectopic pole formation.
J. Bacteriol. 187(2) , 544-53, (2005) Caulobacter crescentus cells treated with amdinocillin, an antibiotic which specifically inhibits the cell elongation transpeptidase penicillin binding protein 2 in Escherichia coli, exhibit defects in stalk elongation and morphology, indicating that stalk sy... |
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Uncomplicated urinary tract infections. Bacterial findings and efficacy of empirical antibacterial treatment.
Scand. J. Prim. Health Care 23(2) , 115-9, (2005) To assess bacterial aetiology, antimicrobial susceptibility and efficacy of empirical treatment in uncomplicated urinary tract infections and to evaluate the dipstick as a diagnostic tool.Prospective study.Clinical microbiology laboratory and 17 general pract... |